Left Temporal Hypometabolism in FDG-PET underlines Cognitive Reserve Hypothesis in Frontotemporal Dementia

Beyer, L.; Meyer-Wilmes, J.; Schönecker, S.; Schnabel, J.; Brendel, E.; Unterrainer, M.; Catak, C.; Pogarell, O.; Perneczky, R.; Danek, A.; Bürger, K.; Bartenstein, P.; Levin, J.; Rominger, Axel Oliver; Brendel, M. (2018). Left Temporal Hypometabolism in FDG-PET underlines Cognitive Reserve Hypothesis in Frontotemporal Dementia. European journal of nuclear medicine and molecular imaging, 45(S1), S408-S408. Springer-Verlag

Introduction: Frontotemporal lobar degeneration as the second most cause of presenile dementia shows a characteristic pattern of hypometabolism in frontal and temporal regions in [18F]-fluordeoxyglucose positron-emission-tomography (FDG-PET). In ageing and dementia, the concept of cognitive reserve as a mediating factor between neuronal injury and clinical symptoms has been proposed for many years. Years of education (YoE) has been demonstrated as a proxy of cognitive reserve in Alzheimer’s disease. We aimed to test how the paradigm of cognitive reserve is reflected in FTD. Subjects and methods: FDG-PET of 93 subjects (age 68 ± 9 years) with FTD were analysed retrospectively. Mini-mental-state-examination (MMSE) and YoE were recorded. A voxel-wise regression analysis was used to identify regional glucose metabolism associated with declining MMSE. Individual FDG-PET values were extracted from the resulting significant cluster (FWE correction, p < 0.05). The residuals of the partial correlation between FDG-PET and MMSE were correlated with YoE. Results: Cognitive deterioration (MMSE) was only correlated with left temporal hypometabolism whereas the contralateral temporal lobe and bilateral frontal cortices did not indicate significant associations. Regression analysis with values deriving from the left temporal cluster indicated a significant positive association with MMSE (β = 0.62, p < 0.001). The residuals of the correlation of FDG-PET and MMSE showed a significant correlation with the YoE (ß = 0.29, p = 0.005). Conclusion: Cognitive decline is mainly associated with left temporal hypometabolism in FTD. Cognitive reserve expressed by a higher level of education is also present in FTD and needs to receive attention as a potential modifying factor in prevention and treatment of FTD.

Item Type:

Conference or Workshop Item (Abstract)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Rominger, Axel Oliver

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1619-7070

Publisher:

Springer-Verlag

Language:

English

Submitter:

Sabine Lanz

Date Deposited:

07 Jun 2019 09:50

Last Modified:

07 Jun 2019 09:50

Additional Information:

EP-0279

URI:

https://boris.unibe.ch/id/eprint/126205

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