Amyloid Imaging using 18F-FIBT PET: a pilot study

Shi, Kuangyu; Grimmer, T.; Förstl, H.; Yakushev, I.; Schwaiger, M.; Weber, W.; Kurz, A.; Yousefi, B.H. (2018). Amyloid Imaging using 18F-FIBT PET: a pilot study. European journal of nuclear medicine and molecular imaging, 45(S1), S133-S133. Springer-Verlag

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Purpose: 2-(p-Methylaminophenyl)-7-(2-[18F]fluoroethoxy)
imidazo[2,1-b]benzothiazole (18F-FIBT) has been reported as
a promising marker for imaging cerebral amyloid deposition
using PET. For further clinical integration, the imaging protocol
and corresponding evaluation method are compared with
11C-PiB and optimized in this pilot study. Methods: Six patients
with different clinical-pathophysiological phenotypes underwent
dynamic PET imaging for 90 min in Siemens Biograph
mMR. For the comparison of different calculation methods,
the patients imaged with dynamic 18F-FIBT were compared to
four patients scanned with dynamic 11C-PiB. For the comparison
of SUVRs, each case imaged with 18F-FIBT was compared to a
group of matched patients (five patients/group) imaged with
11C-PiB. The image data were spatially normalized based on MRI
using PMOD. Images were analyzed by comparing standardized
uptake value ratios (SUVR), binding potentials (BP) obtained using
reference tissue model, and distribution volume ratio (DVR).
Cerebellum was selected as reference tissue region. The effect
of MRI-based partial volume correction (PVC) on interpretation
was also compared. Results: Specific binding was detected
in the cases with underlying AD pathology. The intensities of
BP and SUVR were associated with clinical severity for 18F-FIBT,
which was not observed for 11C-PiB. SNRs were substantially
higher in FIBT than in PiB imaging. The optimal imaging time
for 18F-FIBT was found between 40-60 min. Cases with non-AD
pathology did not show specific binding. BP has higher contrast
than SUVR. However, SUVR is more consistent with the clinical
interpretations. Conclusion: SUVRs PVC correction seemed to
be an easy and robust analyzing technique, making FIBT a favorable
amyloid marker for clinical routine.

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