Amyloid Imaging using 18F-FIBT PET: a pilot study

Shi, Kuangyu; Grimmer, T.; Förstl, H.; Yakushev, I.; Schwaiger, M.; Weber, W.; Kurz, A.; Yousefi, B.H. (2018). Amyloid Imaging using 18F-FIBT PET: a pilot study. European journal of nuclear medicine and molecular imaging, 45(S1), S133-S133. Springer-Verlag

Purpose: 2-(p-Methylaminophenyl)-7-(2-[18F]fluoroethoxy) imidazo[2,1-b]benzothiazole (18F-FIBT) has been reported as a promising marker for imaging cerebral amyloid deposition using PET. For further clinical integration, the imaging protocol and corresponding evaluation method are compared with 11C-PiB and optimized in this pilot study. Methods: Six patients with different clinical-pathophysiological phenotypes underwent dynamic PET imaging for 90 min in Siemens Biograph mMR. For the comparison of different calculation methods, the patients imaged with dynamic 18F-FIBT were compared to four patients scanned with dynamic 11C-PiB. For the comparison of SUVRs, each case imaged with 18F-FIBT was compared to a group of matched patients (five patients/group) imaged with 11C-PiB. The image data were spatially normalized based on MRI using PMOD. Images were analyzed by comparing standardized uptake value ratios (SUVR), binding potentials (BP) obtained using reference tissue model, and distribution volume ratio (DVR). Cerebellum was selected as reference tissue region. The effect of MRI-based partial volume correction (PVC) on interpretation was also compared. Results: Specific binding was detected in the cases with underlying AD pathology. The intensities of BP and SUVR were associated with clinical severity for 18F-FIBT, which was not observed for 11C-PiB. SNRs were substantially higher in FIBT than in PiB imaging. The optimal imaging time for 18F-FIBT was found between 40-60 min. Cases with non-AD pathology did not show specific binding. BP has higher contrast than SUVR. However, SUVR is more consistent with the clinical interpretations. Conclusion: SUVRs PVC correction seemed to be an easy and robust analyzing technique, making FIBT a favorable amyloid marker for clinical routine.

Item Type:

Conference or Workshop Item (Abstract)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Shi, Kuangyu

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1619-7070

Publisher:

Springer-Verlag

Language:

English

Submitter:

Sabine Lanz

Date Deposited:

07 Jun 2019 09:58

Last Modified:

07 Jun 2019 09:58

Additional Information:

OP-407

URI:

https://boris.unibe.ch/id/eprint/126210

Actions (login required)

Edit item Edit item
Provide Feedback