Is Asymmetry of the Pons Associated with Hand Function and Manual Ability after Arterial Ischemic Stroke in Children?

Slavova, Nedelina Bozhidarova; Shojai, Max Philipp; Everts, Regula; Wiest, Roland; Steinlin, Maja; Grunt, Sebastian (2019). Is Asymmetry of the Pons Associated with Hand Function and Manual Ability after Arterial Ischemic Stroke in Children? Neuropediatrics, 50(3), pp. 138-145. Thieme 10.1055/s-0039-1678610

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AIM

This study was designed to investigate how the asymmetry of the brain stem is related to hand function and manual ability after arterial ischemic stroke (AIS) diagnosed during childhood.

METHOD

Patients diagnosed with AIS during childhood (> 5 years old, diagnosis > 2 years before recruitment) and typically developing peers were recruited by the Swiss Neuropediatric Stroke Registry. Brainstem cross-sectional areas of each side at the level of the pons were measured. Pinch and grip strength were measured with a dynamometer, quality of upper limb movement by the Melbourne Assessment 2 and manual ability by the ABILHAND-kids. An asymmetry index was calculated for all measures (except the ABILHAND-kids). Differences between groups and correlations were calculated using nonparametric statistics.

RESULTS

Fourteen AIS survivors without hemiparesis, 10 AIS survivors with hemiparesis, and 47 typically developing peers were assessed. Patients with hemiparesis showed the highest brainstem asymmetry. There was a significant positive correlation between brainstem asymmetry, the asymmetry of strength and quality of upper limb movement, and a significant negative correlation between brainstem asymmetry and manual ability.

INTERPRETATION

In pediatric AIS survivors, brainstem asymmetry can serve as an indirect measure of corticospinal tract integrity. It is significantly correlated with strength, quality of movement, and manual ability.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
UniBE Contributor:	Slavova, Nedelina Bozhidarova, Everts, Regula, Wiest, Roland Gerhard Rudi, Steinlin, Maja, Grunt, Sebastian
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1439-1899
Publisher:	Thieme
Language:	English
Submitter:	Anette van Dorland
Date Deposited:	20 Mar 2019 16:57
Last Modified:	02 Mar 2023 23:31
Publisher DOI:	10.1055/s-0039-1678610
PubMed ID:	30722076
URI:	https://boris.unibe.ch/id/eprint/126221