[Subclinical hypothyroidism : should we still treat elderly patients? Clinical implications of a new trial in primary care].

Collet, Tinh-Hai; Sykiotis, Gerasimos P; Aubert, Carole Elodie; Baumgartner, Christine; Blum, Manuel Raphael; Feller, Martin; Stettler, Christoph; Rodondi, Nicolas (2018). [Subclinical hypothyroidism : should we still treat elderly patients? Clinical implications of a new trial in primary care]. Revue médicale suisse, 14(596), pp. 470-474. Médecine & Hygiène

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Subclinical hypothyroidism, defined as an elevated level of thyrotropin hormone (TSH) and normal thyroxin, is more frequent in women and above 65 years old. This condition is associated with an increased cardiovascular risk, in particular with TSH > 10,0 mIU/L. Although overt hypothyroidism is rare (prevalence of 0,3 %), levothyroxine has become the most prescribed medication in the US, while its indications are still debated. The European-funded TRUST trial showed no improvement in Hypothyroid Symptoms and Tiredness scores among patients ≥ 65 years with subclinical hypothyroidism treated with levothyroxine, and no improvement in blood pressure, weight, muscle strength and cognition. The results of this study call for a revision of the current international recommendations on the treatment of subclinical hypothyroidism.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Aubert, Carole Elodie; Baumgartner, Christine; Blum, Manuel Raphael; Feller, Martin; Stettler, Christoph and Rodondi, Nicolas

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0025-6749

Publisher:

Médecine & Hygiène

Language:

French

Submitter:

Andreas Melmer

Date Deposited:

20 Aug 2019 09:13

Last Modified:

20 Aug 2019 09:22

PubMed ID:

29489127

BORIS DOI:

10.7892/boris.126226

URI:

https://boris.unibe.ch/id/eprint/126226

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