Supervised Short-term High-intensity Training on Plasma Irisin Concentrations in Type 2 Diabetic Patients.

Dünnwald, Tobias; Melmer, Andreas; Gatterer, Hannes; Salzmann, Karin; Ebenbichler, Christoph; Burtscher, Martin; Schobersberger, Wolfgang; Grander, Wilhelm (2019). Supervised Short-term High-intensity Training on Plasma Irisin Concentrations in Type 2 Diabetic Patients. International journal of sports medicine, 40(3), pp. 158-164. Thieme 10.1055/a-0828-8047

Full text not available from this repository. (Request a copy)

Irisin is a myokine involved in adipocyte transformation. Its main beneficial effects arise from increased energy expenditure. Irisin production is particularly stimulated by physical exercise. The present study investigates the changes of plasma irisin in type 2 diabetic patients performing 2 different training modalities. Fourteen type 2 diabetic patients underwent 4 week of supervised high-intensity interval training (HIT; n=8) or continuous moderate-intensity training (CMT; n=6), with equivalent total amounts of work required. Plasma samples were collected in the resting state atbaseline and one day after the exercise intervention to analyse resting plasma irisin, blood lipids, blood glucose, hsCRP, Adiponectin, Leptin and TNF-α concentrations. In addition, body composition and VO were determined Resting plasma irisin increased after HIT (p=0.049) and correlated significantly with plasma fasting glucose at follow-up (r=0.763; p=0.006). CMT did not significantly change the amount of plasma irisin, although follow-up values of plasma irisin correlated negatively with fat-free mass (r=-0.827, p=0.002) and with fasting plasma glucose (r = - 0.934, p=0.006). Plasma irisin was found to increase with higher training intensity, confirming the assumption that exercise intensity, in addition to the type of exercise, may play an important role in the stimulation of the irisin response.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Melmer, Andreas


600 Technology > 610 Medicine & health








Andreas Melmer

Date Deposited:

16 Apr 2019 15:01

Last Modified:

16 Apr 2019 15:01

Publisher DOI:


PubMed ID:



Actions (login required)

Edit item Edit item
Provide Feedback