Comparison of fourteen rule-out strategies for acute myocardial infarction.

Wildi, Karin; Boeddinghaus, Jasper; Nestelberger, Thomas; Twerenbold, Raphael; Badertscher, Patrick; Wussler, Desiree; Giménez, Maria Rubini; Puelacher, Christian; du Fay de Lavallaz, Jeanne; Dietsche, Sebastian; Walter, Joan; Kozhuharov, Nikola; Morawiec, Beata; Miró, Òscar; Javier Martin-Sanchez, F; Subramaniam, Sinthuri; Geigy, Nicolas; Keller, Dagmar I; Reichlin, Tobias Roman and Mueller, Christian (2019). Comparison of fourteen rule-out strategies for acute myocardial infarction. International journal of cardiology, 283, pp. 41-47. Elsevier 10.1016/j.ijcard.2018.11.140

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BACKGROUND The clinical availability of high-sensitivity cardiac troponin (hs-cTn) has enabled the development of several innovative strategies for the rapid rule-out of acute myocardial infarction (AMI). Due to the lack of direct comparisons, selection of the best strategy for clinical practice is challenging. METHODS In a prospective international multicenter diagnostic study enrolling 3696 patients presenting with suspected AMI to the emergency department, we compared the safety and efficacy of 14 different hs-cTn-based strategies: hs-cTn concentrations below the limit of detection (LoD), dual-marker combining hs-cTn with copeptin, ESC 0 h/1 h-algorithm, 0 h/2 h-algorithm, 2 h-ADP-algorithm, NICE-algorithm, and ESC 0 h/3 h-algorithm, each using either hs-cTnT or hs-cTnI. The final diagnosis of AMI was adjudicated by two independent cardiologists using all available clinical information including cardiac imaging and serial hs-cTn concentrations. RESULTS AMI was the final diagnosis in 16% of patients. Using hs-cTnT, safety quantified by the negative predictive value (NPV) and sensitivity was very high (99.8-100% and 99.5-100%) and comparable for all strategies, except the dual-marker approach (NPV 98.7%, sensitivity 96.7%). Similarly, using hs-cTnI, safety quantified by the NPV and sensitivity was very high (99.7-100% and 98.9-100%) and comparable for all strategies, except the dual-marker approach (NPV 96.9%, sensitivity 90.4%) and the NICE-algorithm (NPV 99.1%, sensitivity 94.7%). Efficacy, quantified by the percentage of patients eligible for rule-out, differed markedly, and was lowest for LoD-algorithm (15.7-26.8%). CONCLUSION All rapid rule-out algorithms, except the dual-marker strategy and the NICE-algorithm using hs-cTnI, favorably combine safety and efficacy, and can be considered for routine clinical practice. CLINICAL TRIAL REGISTRATION NCT00470587,

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Reichlin, Tobias Roman


600 Technology > 610 Medicine & health








Tobias Roman Reichlin

Date Deposited:

21 Feb 2019 14:45

Last Modified:

25 Oct 2019 14:42

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Acute myocardial infarction Diagnosis Efficacy High-sensitivity cardiac troponin T and I Rule-out Rule-out algorithm




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