Prospective validation of prognostic and diagnostic syncope scores in the emergency department.

du Fay de Lavallaz, Jeanne; Badertscher, Patrick; Nestelberger, Thomas; Isenrich, Rahel; Miró, Òscar; Salgado, Emilio; Geigy, Nicolas; Christ, Michael; Cullen, Louise; Than, Martin; Martin-Sanchez, F Javier; Bustamante Mandrión, José; Di Somma, Salvatore; Peacock, W Frank; Kawecki, Damian; Boeddinghaus, Jasper; Twerenbold, Raphael; Puelacher, Christian; Wussler, Desiree; Strebel, Ivo; ... (2018). Prospective validation of prognostic and diagnostic syncope scores in the emergency department. International journal of cardiology, 269, pp. 114-121. Elsevier 10.1016/j.ijcard.2018.06.088

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BACKGROUND Various scores have been derived for the assessment of syncope patients in the emergency department (ED) but stay inconsistently validated. We aim to compare their performance to the one of a common, easy-to-use CHADS score. METHODS We prospectively enrolled patients ≥ 40 years old presenting with syncope to the ED in a multicenter study. Early clinical judgment (ECJ) of the treating ED-physician regarding the probability of cardiac syncope was quantified. Two independent physicians adjudicated the final diagnosis after 1-year follow-up. Major cardiovascular events (MACE) and death were recorded during 2 years of follow-up. Nine scores were compared by their area under the receiver-operator characteristics curve (AUC) for death, MACE or the diagnosis of cardiac syncope. RESULTS 1490 patients were available for score validation. The CHADS-score presented a higher or equally high accuracy for death in the long- and short-term follow-up than other syncope-specific risk scores. This score also performed well for the prediction of MACE in the long- and short-term evaluation and stratified patients with accuracy comparative to OESIL, one of the best performing syncope-specific risk score. All scores performed poorly for diagnosing cardiac syncope when compared to the ECJ. CONCLUSIONS The CHADS-score performed comparably to more complicated syncope-specific risk scores in the prediction of death and MACE in ED syncope patients. While better tools incorporating biochemical and electrocardiographic markers are needed, this study suggests that the CHADS-score is currently a good option to stratify risk in syncope patients in the ED. TRIAL REGISTRATION NCT01548352.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Reichlin, Tobias Roman


600 Technology > 610 Medicine & health








Tobias Roman Reichlin

Date Deposited:

27 Feb 2019 10:32

Last Modified:

05 Dec 2019 09:45

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Diagnosis Emergency department Scores Syncope




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