Starch Wars-New Episodes of the Saga. Changes in Regulations on Hydroxyethyl Starch in the European Union.

Adamik, Katja; Yozova, Ivayla (2019). Starch Wars-New Episodes of the Saga. Changes in Regulations on Hydroxyethyl Starch in the European Union. Frontiers in veterinary science, 5(336), p. 336. Frontiers Media 10.3389/fvets.2018.00336

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After a safety review of hydroxyethyl starch (HES) solutions in 2013, restrictions on the use of HES were introduced in the European Union (EU) to reduce the risk of kidney injury and death in certain patient populations. Similar restrictions were introduced by the Food and Drug Administration in the United States and other countries. In October 2017, a second safety review of HES solutions was triggered by the European pharmacovigilance authorities based on a request by the Swedish Medical Products Agency to completely suspend HES. After several meetings and repeated evaluations, the recommendation to ban HES was ultimately not endorsed by the responsible committee; however, there was a vote for more restricted access to the drug and rigorous monitoring of policy adherence. This review delineates developments in the European pharmacovigilance risk assessment of HES solutions between 2013 and 2018. In addition, the divergent experts' opinions and the controversy surrounding this official assessment are described. As the new decisions might influence the availability of HES products for veterinary patients, potential alternatives to HES solutions, such as albumin solutions and gelatin, are briefly discussed.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Intensive Care Unit, Small Animal Clinic

UniBE Contributor:

Adamik, Katja and Yozova, Ivayla

Subjects:

600 Technology > 630 Agriculture

ISSN:

2297-1769

Publisher:

Frontiers Media

Language:

English

Submitter:

Katja Adamik

Date Deposited:

08 Apr 2019 17:45

Last Modified:

25 Oct 2019 02:30

Publisher DOI:

10.3389/fvets.2018.00336

PubMed ID:

30713845

Uncontrolled Keywords:

Hydroxyethyl starch

BORIS DOI:

10.7892/boris.126455

URI:

https://boris.unibe.ch/id/eprint/126455

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