Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation.

Kim, Soung Yung; Völkl, Simon; Ludwig, Stephan; Schneider, Holm; Wixler, Viktor; Park, Jung (2019). Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation. Journal of cell science, 132(6) Company of Biologists Limited 10.1242/jcs.228940

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Fhl2 (Four and a half LIM domain protein 2) is an adaptor protein capable of mediating protein-protein interactions. Here, we report for the first time phenotypic changes in the brain of Fhl2-deficient mice. We showed that: (i) Fhl2 is expressed in neural stem cells, precursors, and mature cells of the neuronal lineage; (ii) Fhl2 deficiency leads to delayed neuroblast migration , to (iii) premature astroglial differentiation of neural stem cells (NSC) , and to (iv) a gliosis-like accumulation of GFAP+ astrocytes that substantially increases with age. Collectively, Fhl2-deficiency in the brain interrupts the maintenance and the balanced differentiation of adult NSC, resulting in preferentially glial differentiation and early exhaustion of the NSC pool required for adult neurogenesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Kim, Soung Yung

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0021-9533

Publisher:

Company of Biologists Limited

Language:

English

Submitter:

Isabelle Ursula Saurer

Date Deposited:

20 May 2019 13:43

Last Modified:

24 Oct 2019 12:24

Publisher DOI:

10.1242/jcs.228940

PubMed ID:

30745335

Uncontrolled Keywords:

Adult neurogenesis Fhl2 (Four and a half LIM domain protein 2) Gliogenesis Neural stem cells

BORIS DOI:

10.7892/boris.126588

URI:

https://boris.unibe.ch/id/eprint/126588

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