Characterization of the electrical conductivity of bone and its correlation to osseous structure.

Balmer, Thomas Wyss; Vesztergom, Soma; Broekmann, Peter; Stahel, Andreas; Büchler, Philippe (2018). Characterization of the electrical conductivity of bone and its correlation to osseous structure. Scientific Reports, 8(1), p. 8601. Nature Publishing Group 10.1038/s41598-018-26836-0

[img]
Preview
Text
Balmer et al. - 2018 - Characterization of the electrical conductivity of bone and its correlation to osseous structure.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

The interaction of osseous tissue with electric fields is an important subject. The electrical stimulation of bone promotes osteogenesis, while bone impedance has been proposed as a measure of osteoporosis, to follow fracture healing, or as a method to improve safety of surgical procedures. However, a deeper understanding of the electrical properties of bone and their relation to the architecture of osseous tissue is required to extend the range of use of electrical measurements to clinical studies. In this paper we apply electrical impedance spectroscopy to study the conductivity of fresh bovine tibia and we correlate the measured conductivities with its structural properties. Impedance was measured using a custom-made cell and a potentiostat. Bone conductivity was determined at 100 kHz, where the phase shift was negligible. A good agreement (R = 0.83) was found between the measured conductivity and the bone volume fraction, determined on microCT images. Based on this relationship, an equivalent circuit model was created for bone samples. The results of this ex-vivo study are comparable to previous in-vivo observations reporting bone resistivity as a function of bone density. This information can be used to construct a map of the tissue resistivity directly derived from clinical images.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy > ARTORG Center - Artificial Hearing Research
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Balmer, Thomas Wyss; Vesztergom, Soma; Broekmann, Peter and Büchler, Philippe

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Philippe Büchler

Date Deposited:

22 May 2019 10:18

Last Modified:

26 May 2019 02:34

Publisher DOI:

10.1038/s41598-018-26836-0

PubMed ID:

29872230

BORIS DOI:

10.7892/boris.126715

URI:

https://boris.unibe.ch/id/eprint/126715

Actions (login required)

Edit item Edit item
Provide Feedback