Swept-source optical coherence tomography angiography reveals vascular changes in intermediate uveitis.

Tian, Meng; Tappeiner, Christoph; Zinkernagel, Martin; Wolf, Sebastian; Munk, Marion (2019). Swept-source optical coherence tomography angiography reveals vascular changes in intermediate uveitis. Acta ophthalmologica, 97(5), e785-e791. Wiley 10.1111/aos.14024

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PURPOSE To evaluate retinal and choroidal vascular changes in patients with intermediate uveitis with/without concomitant retinal vasculitis using wide field swept-source optical coherence tomography angiography (OCTA). METHODS In this study consecutive patients with intermediate uveitis ± vasculitis and healthy age-matched controls were evaluated using central 3 × 3 mm OCTA scans and montage scans. Differences among the groups as well as the association between central changes assessed by 3 × 3 scans and wide field OCTA were evaluated. RESULTS 93 eyes of 58 patients with intermediate uveitis and 33 healthy age-matched controls were included. The presence of a cystoid macular oedema (CME) was associated with capillary non-and reduced perfusion of the superficial capillary plexus (SCP) (p = 0.03 and 0.02, respectively), and deep capillary plexus (DCP) (p = 0.02 and p ≤ 0.0001, respectively) of the 3 × 3 mm scans. The raw length, circularity and size of foveal avascular area (FAZ) significantly differed among the three groups. (p = 0.01, p = 0.045 and p = 0.004, respectively). Multivariable regression analysis revealed that the presence of epiretinal membranes (ERM) and CME rather than the disease entity contributed to the changes of FAZ size (R  = 0.15, p = 0.0003) The mean vessel density (VD) of the SCP significantly differed among the three groups (intermediate uveitis with concomitant vasculitis: 16.8 ± 3.8 mm vs intermediate uveitis only: 15.6 ± 4.4 mm versus control: 18 ± 3.5 mm , p = 0.046). Multivariable regression analysis showed that the presence of CME rather than the disease entity impacted vessel density of SCP (R  = 0.1, p = 0.016). There was no association between peripheral non- or reduced perfusion of the wide field OCTA slabs of the SCP and DCP and the VD of the 3 × 3 slabs. CONCLUSION Although patients with intermediate uveitis and vasculitis present with reduced central vessel density compared to healthy age-matched controls, these changes are presumably contributed to the presence of CME.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Augenklinik > Forschungsgruppe Augenheilkunde

UniBE Contributor:

Tappeiner, Christoph; Zinkernagel, Martin; Wolf, Sebastian and Munk, Marion

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1755-3768

Publisher:

Wiley

Language:

English

Submitter:

Marion Munk

Date Deposited:

20 Feb 2019 15:33

Last Modified:

24 Oct 2019 11:59

Publisher DOI:

10.1111/aos.14024

PubMed ID:

30729711

Uncontrolled Keywords:

foveal avascular zone parameter intermediate uveitis optical coherence tomography angiography (OCTA) retinal vasculitis vessel density

BORIS DOI:

10.7892/boris.126738

URI:

https://boris.unibe.ch/id/eprint/126738

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