Simulating Brain Tumour Mass-Effect

Abler, Daniel; Büchler, Philippe; Rockne, Russell C. (March 2018). Simulating Brain Tumour Mass-Effect (Unpublished). In: FEniCS Conference. Oxford, UK. March 2018.

Glioblastoma (GBM) is the most frequent malignant brain tumour in adults. Its growth is characterized by infiltration of surrounding healthy tissue, and the formation of a necrotic core. GBM presents with varying degree of mass-effect which results in healthy-tissue deformation, midline shift or herniation. Biomechanical forces, such as those resulting from displacive tumour growth, shape the tumour environment, contribute to tumour progression and may affect treatment response and outcome. To investigate the role of tumour mass-effect for tumour evolution, we have previously developed a mechanically-coupled reaction-diffusion model that captures three dominant aspects of macroscopic GBM growth: (a) tumour cell proliferation, (b) the diffuse invasion of the growing tumour into surrounding healthy tissue, and (c) the resulting mass effect. Here we present an implementation of this model in FENICS and first steps towards an image-based optimization approach, based on dolphin-adjoint, to estimate patient-specific parameters from clinical magnetic-resonance imaging (MRI).

Item Type:

Conference or Workshop Item (Speech)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

UniBE Contributor:

Abler, Daniel and Büchler, Philippe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

Funders:

[124] H2020-MSCA-IF-2016 Project ID 753878

Language:

English

Submitter:

Daniel Jakob Silvester Abler

Date Deposited:

06 Sep 2019 15:46

Last Modified:

06 Sep 2019 15:46

URI:

https://boris.unibe.ch/id/eprint/126748

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