Comparison of All-Cause and Cause-Specific Mortality of Persons with Traumatic Spinal Cord Injuries to the General Swiss Population: Results from a National Cohort Study.

Chamberlain, Jonviea D; Buzzell, Anne; Gmünder, Hans Peter; Hug, Kerstin; Jordan, Xavier; Moser, André; Schubert, Martin; Zwahlen, Marcel; Brinkhof, Martin W G (2019). Comparison of All-Cause and Cause-Specific Mortality of Persons with Traumatic Spinal Cord Injuries to the General Swiss Population: Results from a National Cohort Study. Neuroepidemiology, 52(3-4), pp. 205-213. Karger 10.1159/000496976

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BACKGROUND Traumatic spinal cord injuries (TSCI) are a neurological condition associated with reduced well-being, increased morbidity and reductions in life expectancy. Estimates of all-cause and cause-specific mortality can aid in identifying targets for prevention and management of contributors for premature mortality. OBJECTIVES To compare all-cause and cause-specific rates of mortality to that of the Swiss general population; to identify differentials in risk of cause-specific mortality according to lesion characteristics. METHODS All-cause and cause-specific standardized mortality ratios (SMRs) were calculated using data from the Swiss Spinal Cord Injury cohort study. Cause-specific subhazard ratios were estimated within a competing risk framework using flexible parametric survival models. RESULTS Between 1990 and 2011, 2,492 persons sustained a TSCI, of which 379 died. Persons with TSCI had a mortality rate more than 2 times higher than that of the Swiss general population (SMR 2.32; 95% CI 2.10-2.56). Tetraplegic lesions were associated with an increased risk of mortality due to respiratory and cardiovascular diseases, infections, and accidents. Cause-specific SMRs were notably elevated for SCI-related conditions such as urinary tract infections (UTIs) and septicemia. CONCLUSIONS Elevated SMRs due to cardiovascular disease, UTIs and septicemia-related mortality suggest the need for innovation when managing associated secondary health conditions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Zwahlen, Marcel

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0251-5350

Publisher:

Karger

Language:

English

Submitter:

Beatrice Minder Wyssmann

Date Deposited:

28 Feb 2019 16:24

Last Modified:

23 Oct 2019 02:35

Publisher DOI:

10.1159/000496976

PubMed ID:

30763935

Uncontrolled Keywords:

Epidemiology Mortality Spinal cord injury Standardized mortality ratio

BORIS DOI:

10.7892/boris.127045

URI:

https://boris.unibe.ch/id/eprint/127045

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