Hounsfield unit values of liver pathologies in unenhanced post-mortem computed tomography.

Tisch, Carmen; Brencicová, Eva; Schwendener, Nicole; Lombardo, Paolo; Jackowski, Christian; Zech, Wolf-Dieter (2019). Hounsfield unit values of liver pathologies in unenhanced post-mortem computed tomography. (In Press). International journal of legal medicine Springer 10.1007/s00414-019-02016-1

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BACKGROUND The goal of this study was to evaluate if unenhanced PMCT HU values of liver pathologies differ from post-mortem HU values of non-pathologic liver tissue. METHODS Liver HU values were measured in five liver segments in PMCT unenhanced datasets of 214 forensic cases (124 male, 90 female, mean age 54.3 years). Liver HU values were compared with corresponding histologic liver findings. HU values of non-pathologic livers were compared to HU values of liver pathologies. RESULTS A total of 64 non-pathologic livers (mean HU 58.32, SD 8.91) were assessed. Histologic diagnosed liver pathologies were as follows: steatosis (n = 121 (grade I n = 61, grade II n = 37, grade III n = 23)), fibrosis (n = 10), and cirrhosis (n = 19). HU values of the livers exhibiting severe steatosis (mean HU 32.44, SD 13.76), fibrosis (mean HU 44.7, SD 16.31), and cirrhosis (mean HU 50.59, SD 9.42) significantly differed to HU values of non-pathologic livers at ANOVA testing. CONCLUSION PMCT unenhanced liver HU value measurements may be used as an additional method to detect unspecific liver-pathology. Values below 30 HU may specifically indicate severe steatosis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Brencicová, Eva; Schwendener, Nicole; Lombardo, Paolo; Jackowski, Christian and Zech, Wolf-Dieter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0937-9827

Publisher:

Springer

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

17 Apr 2019 15:57

Last Modified:

01 May 2019 13:42

Publisher DOI:

10.1007/s00414-019-02016-1

PubMed ID:

30788563

Uncontrolled Keywords:

Cirrhosis Fibrosis Hounsfield unit Liver Steatosis Unenhanced post-mortem computed tomography

BORIS DOI:

10.7892/boris.127160

URI:

https://boris.unibe.ch/id/eprint/127160

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