Patterns of homozygosity in insular and continental goat breeds.

Cardoso, Taina F; Amills, Marcel; Bertolini, Francesca; Rothschild, Max; Marras, Gabriele; Boink, Geert; Jordana, Jordi; Capote, Juan; Carolan, Sean; Hallsson, Jón H; Kantanen, Juha; Pons, Agueda; Lenstra, Johannes A; AdaptMap, Consortium (2018). Patterns of homozygosity in insular and continental goat breeds. Genetics, selection, evolution, 50(1), p. 56. BioMed Central 10.1186/s12711-018-0425-7

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BACKGROUND Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 individuals from 25 European and African breeds with the Goat SNP50 BeadChip and comparing patterns of homozygosity of insular and nearby continental breeds. RESULTS Among the breeds analysed, number and total length of ROH varied considerably and depending on breeds, ROH could cover a substantial fraction of the genome (up to 1.6 Gb in Icelandic goats). When compared with their continental counterparts, goats from Iceland, Madagascar, La Palma and Ireland (Bilberry and Arran) displayed a significant increase in ROH coverage, ROH number and F values (P value < 0.05). Goats from Mediterranean islands represent a more complex case because certain populations displayed a significantly increased level of homozygosity (e.g. Girgentana) and others did not (e.g. Corse and Sarda). Correlations of number and total length of ROH for insular goat populations with the distance between islands and the nearest continental locations revealed an effect of extremely long distances on the patterns of homozygosity. CONCLUSIONS These results indicate that the effects of insularization on the patterns of homozygosity are variable. Goats raised in Madagascar, Iceland, Ireland (Bilberry and Arran) and La Palma, show high levels of homozygosity, whereas those bred in Mediterranean islands display patterns of homozygosity that are similar to those found in continental populations. These results indicate that the diversity of insular goat populations is modulated by multiple factors such as geographic distribution, population size, demographic history, trading and breed management.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

1297-9686

Publisher:

BioMed Central

Language:

English

Submitter:

Cord Drögemüller

Date Deposited:

29 May 2019 12:16

Last Modified:

22 Oct 2019 17:09

Publisher DOI:

10.1186/s12711-018-0425-7

PubMed ID:

30449277

Additional Information:

Cord Drögemüller is a member of the AdaptMap Consortium

BORIS DOI:

10.7892/boris.127323

URI:

https://boris.unibe.ch/id/eprint/127323

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