Development of an International Canine Spinal Cord Injury observational registry: a collaborative data-sharing network to optimize translational studies of SCI.

Moore, SA; Zidan, N; Spitzbarth, I; Nout-Lomas, YS; Granger, N; da Costa, RC; Levine, JM; Jeffery, ND; Stein, Veronika Maria; Tipold, A; Olby, NJ (2018). Development of an International Canine Spinal Cord Injury observational registry: a collaborative data-sharing network to optimize translational studies of SCI. Spinal cord, 56(7), pp. 656-665. Nature Publishing Group 10.1038/s41393-018-0145-4

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STUDY DESIGN:

Prospective cross-sectional cohort study.
OBJECTIVES:

The canine spontaneous model of spinal cord injury (SCI) is as an important pre-clinical platform as it recapitulates key facets of human injury in a naturally occurring context. The establishment of an observational canine SCI registry constitutes a key step in performing epidemiologic studies and assessing the impact of therapeutic strategies to enhance translational research. Further, accumulating information on dogs with SCI may contribute to current "big data" approaches to enhance understanding of the disease using heterogeneous multi-institutional, multi-species datasets from both pre-clinical and human studies.
SETTING:

Multiple veterinary academic institutions across the United States and Europe.
METHODS:

Common data elements recommended for experimental and human SCI studies were reviewed and adapted for use in a web-based registry, to which all dogs presenting to member veterinary tertiary care facilities were prospectively entered over ~1 year.
RESULTS:

Analysis of data accumulated during the first year of the registry suggests that 16% of dogs with SCI present with severe, sensorimotor-complete injury and that 15% of cases are seen by a tertiary care facility within 8 h of injury. Similar to the human SCI population, 34% were either overweight or obese.
CONCLUSIONS:

Severity of injury and timing of presentation suggests that neuroprotective studies using the canine clinical model could be conducted efficiently using a multi-institutional approach. Additionally, pet dogs with SCI experience similar comorbidities to people with SCI, in particular obesity, and could serve as an important model to evaluate the effects of this condition.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Stein, Veronika Maria

Subjects:

600 Technology > 630 Agriculture

ISSN:

1362-4393

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Veronika Maria Stein

Date Deposited:

13 May 2019 11:45

Last Modified:

25 Oct 2019 02:54

Publisher DOI:

10.1038/s41393-018-0145-4

PubMed ID:

29795173

BORIS DOI:

10.7892/boris.127365

URI:

https://boris.unibe.ch/id/eprint/127365

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