Therapeutic strategies for eosinophilic dermatoses.

Simon, Dagmar; Simon, Hans-Uwe (2019). Therapeutic strategies for eosinophilic dermatoses. Current opinion in pharmacology, 46, pp. 29-33. Elsevier 10.1016/j.coph.2019.01.002

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Eosinophil infiltration is observed in a broad spectrum of skin diseases of various origins. Eosinophils are thought to actively contribute to pathogenesis as they are able to defend against microbes, to regulate inflammation, cause tissue damage, promote remodeling and fibrosis, and initiate pruritus. Therefore, targeting eosinophils would seem a worthwhile therapeutic approach. A promising strategy is to target the production, activation and survival of eosinophils, example with antibodies directed against IL-5 or its receptor, and Siglec-8. Dexpramipexole and tyrosine kinase inhibitors have been shown to reduce eosinophil numbers in patients with hypereosinophilia. Janus kinase inhibitors block signal transduction and thus activation of inflammatory cells including eosinophils. A further approach is to target cells and cytokines acting on or mediators released by eosinophils, for example, CD52, IL-13, IL-31, TSLP, and eotaxins. This review summarizes current therapeutic strategies, including novel agents affecting eosinophils directly that are under clinical investigation.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Simon, Dagmar and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1471-4973

Publisher:

Elsevier

Language:

English

Submitter:

Sabrina Cookman

Date Deposited:

23 Apr 2019 11:40

Last Modified:

25 Aug 2019 01:31

Publisher DOI:

10.1016/j.coph.2019.01.002

PubMed ID:

30743138

BORIS DOI:

10.7892/boris.127433

URI:

https://boris.unibe.ch/id/eprint/127433

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