Within-breath changes in respiratory system impedance in children with cystic fibrosis.

Zannin, Emanuela; Nyilas, Sylvia; Ramsey, Kathryn A.; Latzin, Philipp; Dellaca', Raffaele L (2019). Within-breath changes in respiratory system impedance in children with cystic fibrosis. Pediatric pulmonology, 54(6), pp. 737-742. Wiley-Blackwell 10.1002/ppul.24281

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BACKGROUND The aim of this study was to assess within-breath respiratory system impedance by the forced oscillation technique (FOT) in children with cystic fibrosis (CF) and relate it to the underlying lung disease. METHODS Thirty-three children with CF (median [range] age 12.0 [6-17] years) underwent FOT at 8 Hz during tidal breathing, multiple breath nitrogen washout (LCI), spirometry (FEV1), body plethysmography (RV/TLC), and magnetic resonance imaging (MRI). FOT outcomes included: mean inspiratory, expiratory, and whole breath resistance (R8 , R8 , R8 ) and reactance (X8 , X8 , X8 ), and the differences between X8 and X8 (ΔX8). Morphological changes were evaluated by MRI using CF-specific morphological scores. Spearman correlation was performed to examine the correlation between FOT indices and other parameters. RESULTS FEV1 was negatively correlated with R8 (r = -0.52, P = 0.002) and ΔX8 (r = -0.55, P = 0.001), and positively correlated with and X8 (r = 0.56, P < 0.001). RV/TLC was positively correlated with R8 (r = 0.43, P = 0.013), and ΔX8 (r = 0.54, P = 0.001) and negatively correlated with X8 (r = -0.54, P = 0.001). We found poor correlation between FOT parameters and LCI and no correlation between FOT parameters and MRI scores. CONCLUSION In children with CF, changes in within-breath FOT parameters are consistent with peripheral obstruction and dynamic airway compression, while they are not associated with ventilation heterogeneities and morphological alterations.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Nyilas, Sylvia Meryl; Ramsey, Kathryn Angela and Latzin, Philipp


600 Technology > 610 Medicine & health








Maria de Fatima Henriques Bernardo

Date Deposited:

25 Apr 2019 10:30

Last Modified:

06 Jan 2020 09:32

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

cystic fibrosis respiratory system impedance within-breath forced oscillation technique





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