Border Disease Virus Infection of Bovine Placentas.

Fernández, Miguel; Braun, Ueli; Frei, Sandra; Schweizer, Matthias; Hilbe, Monika (2018). Border Disease Virus Infection of Bovine Placentas. Veterinary pathology, 55(3), pp. 425-433. Sage 10.1177/0300985817754123

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Subsequent to a previous study of border disease virus (BDV) horizontal transmission from a persistently BDV-infected calf to 6 seronegative pregnant heifers, the heifers were slaughtered 60 days after exposure to the infected calf, and their fetuses and placentas were examined. Immunohistochemical examination of fetal organs and placenta showed positive labeling of moderate intensity for pestivirus antigen in 3 of 6 heifers. BDV infection in these 3 animals was confirmed by the detection of BDV RNA in different organs using reverse transcription quantitative polymerase chain reaction. In the placenta, the positive cells were visualized mostly on the fetal side. In those 3 heifers that harbored an infected fetus, the placental tissue in the placentome region showed a moderate to severe mononuclear and fibrosing placentitis and, in severe cases, necrotic areas. The inflammatory population was composed predominantly of T and B cells, a substantial number of macrophages, and, to a lesser extent, plasma cells. This is a novel report of placentitis in persistently BDV-infected fetuses from pregnant heifers that became acutely infected by cohousing with a calf persistently infected with BDV, which extends previous reports on bovine viral diarrhea virus-infected and BDV-infected cattle and sheep, respectively.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Schweizer, Matthias

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture

ISSN:

1544-2217

Publisher:

Sage

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

03 Jun 2019 11:48

Last Modified:

03 Jun 2019 11:56

Publisher DOI:

10.1177/0300985817754123

PubMed ID:

29402208

Uncontrolled Keywords:

border disease virus bovine viral diarrhea virus cattle inflammation pathology pestivirus placenta placentitis

BORIS DOI:

10.7892/boris.127497

URI:

https://boris.unibe.ch/id/eprint/127497

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