A cross-species approach to disorders affecting brain and behaviour.

Devinsky, Orrin; Boesch, Jordyn M; Cerda-Gonzalez, Sofia; Coffey, Barbara; Davis, Kathryn; Friedman, Daniel; Hainline, Brian; Houpt, Katherine; Lieberman, Daniel; Perry, Pamela; Prüss, Harald; Samuels, Martin A; Small, Gary W; Volk, Holger; Summerfield, Artur; Vite, Charles; Wisniewski, Thomas; Natterson-Horowitz, Barbara (2018). A cross-species approach to disorders affecting brain and behaviour. Nature reviews. Neurology, 14(11), pp. 677-686. Nature Publishing Group 10.1038/s41582-018-0074-z

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Structural and functional elements of biological systems are highly conserved across vertebrates. Many neurological and psychiatric conditions affect both humans and animals. A cross-species approach to the study of brain and behaviour can advance our understanding of human disorders via the identification of unrecognized natural models of spontaneous disorders, thus revealing novel factors that increase vulnerability or resilience, and via the assessment of potential therapies. Moreover, diagnostic and therapeutic advances in human neurology and psychiatry can often be adapted for veterinary patients. However, clinical and research collaborations between physicians and veterinarians remain limited, leaving this wealth of comparative information largely untapped. Here, we review pain, cognitive decline syndromes, epilepsy, anxiety and compulsions, autoimmune and infectious encephalitides and mismatch disorders across a range of animal species, looking for novel insights with translational potential. This comparative perspective can help generate novel hypotheses, expand and improve clinical trials and identify natural animal models of disease resistance and vulnerability.

Item Type:	Journal Article (Review Article)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology 05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
UniBE Contributor:	Summerfield, Artur
Subjects:	600 Technology > 630 Agriculture 500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health
ISSN:	1759-4766
Publisher:	Nature Publishing Group
Language:	English
Submitter:	Pamela Schumacher
Date Deposited:	05 Jun 2019 09:22
Last Modified:	05 Dec 2022 15:27
Publisher DOI:	10.1038/s41582-018-0074-z
PubMed ID:	30287906
URI:	https://boris.unibe.ch/id/eprint/127518