Early Initiation of Anti-Tnf is Associated with Favourable Long-Term Outcome in Crohn's Disease: 10-Year-Follow-Up Data from the Swiss IBD Cohort Study.

Frei, Roy; Fournier, Nicolas; Zeitz, Jonas; Scharl, Michael; Morell, Bernhard; Greuter, Thomas; Schreiner, Philipp; Misselwitz, Benjamin; Safroneeva, Ekaterina; Schoepfer, Alain M; Vavricka, Stephan R; Rogler, Gerhard; Biedermann, Luc (2019). Early Initiation of Anti-Tnf is Associated with Favourable Long-Term Outcome in Crohn's Disease: 10-Year-Follow-Up Data from the Swiss IBD Cohort Study. Journal of Crohn's & Colitis, 13(10), pp. 1292-1301. Elsevier 10.1093/ecco-jcc/jjz057

[img] Text
Frei JCrohnsColitis 2019_postprint.pdf - Accepted Version
Restricted to registered users only until 8 March 2020.
Available under License Publisher holds Copyright.

Download (957kB) | Request a copy

BACKGROUND AND AIMS The optimal timing of treatment escalation in Crohn's disease (CD) remains a challenge and very little is known about its long-term development following early versus late administration of anti-TNF antibodies. The long-term outcome of Swiss CD patients was comparatively assessed in an up to 10-year follow-up, using patients participating in the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). METHODS Prospectively-collected SIBDCS patient data, including disease history, baseline characteristics at enrolment and course of disease were analysed in patients with early versus late (<24 versus >=24 months after diagnosis) and no anti-TNF treatment. RESULTS A reduced risk of developing bowel stenosis was found in patients who received early anti-TNF treatment. This association was seen in patients overall and also in the subgroups of CD patients without pre-existing complications (Log-rank test: p<0.001).Furthermore, osteoporosis and anaemia were observed significantly less frequently in patients who received early anti-TNF treatment, compared to either patients who received treatment late (p<0.001 and p=0.046, respectively) or were never (p<0.001 for both) treated with anti-TNF antibodies. Patients with early anti-TNF administration sought medical consultations significantly less often, including gastroenterologists in private practice (p=0.017), ambulatory (outpatient) hospital visits (p=0.038) and a composite of any medical visits (p=0.001). The percentage of patients unable to work was lowest for early anti-TNF treated patients, in comparison to patients who were treated late or never (3.6% versus 8.8% versus 3.7%, p=0.016). CONCLUSIONS Early anti-TNF administration was found to be associated with several indicators of a more favourable long-term outcome, in CD patients within the SIBDCS.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Safroneeva, Ekaterina


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Doris Kopp Heim

Date Deposited:

21 Mar 2019 09:19

Last Modified:

24 Oct 2019 03:32

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

anti-TNF early intervention long-term outcome





Actions (login required)

Edit item Edit item
Provide Feedback