Neurophysiological correlates of context-dependent inhibition in alcohol use disorder - findings from event-related potentials and fMRI

Stein, Maria; Fey, Werner Martin; Steiner, Leonie; Federspiel, Andrea; König, Thomas; Moggi, Franz (27 November 2018). Neurophysiological correlates of context-dependent inhibition in alcohol use disorder - findings from event-related potentials and fMRI (Unpublished). In: DGPPN. Berlin. 25.-28. November 2018.

Other (Poster)
DGPPN_Stein3.pdf - Presentation
Available under License BORIS Standard License.

Download (312kB) | Preview

Introduction: Alcohol use disorder (AUD) is characterized by both impaired inhibitory control and enhanced cue reactivity, including drinking urges and craving. Therefore, it seems important to investigate inhibitory functions not only in neutral contexts but also in the presence of alcohol-related cues. The present study investigates how exposure to alcohol-related cues affects neural processing of inhibitory control in subjects with (AUD).
Method: Functional magnetic resonance imaging (fMRI) and 72-channel EEG was recorded during performance of an Go/NoGo task, which incorporated alcohol-related and neutral stimuli as Go and NoGo trials in abstinent AUD patients and healthy controls.
Results: No behavioral performance deficits in the AUD group were observed. However, fMRI Data showed increased activation of the fronto-striatal-parietal network in AUD patients during successful response inhibition relative to HC. Within the AUD group, analyses revealed enhanced activation for alcohol-related (relative to neutral) NoGo trials in regions including bilateral anterior cingulate cortex, right medial frontal and precental gyrus and right putamen. Activation differences in the right anterior cingulate cortex furthermore varied with subjective craving (drinking urges). Similarly ERP analyses revealed alterations in the N2 and P3 component of the NoGo-evoked potentials, which were stronger in thecontext of alcohol-related cues. In the N2, the strength of these alterations also varied with subjective drinking urges.
Discussion: These findings suggest that AUD patients need to recruit enhanced neuronal resources in order to successfully inhibit a prepotent response. This hyperactivation is particularly enhanced when inhibition has to take place in an alcohol-related context and is related to craving r drinking urges. These results enrich our understanding of the imbalance between impaired inhibitory control and increased cue reactivity in patients with AUD.

Item Type:

Conference or Workshop Item (Poster)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy

UniBE Contributor:

Stein, Maria, Fey, Werner Martin, Federspiel, Andrea, König, Thomas, Moggi, Franz (A)


600 Technology > 610 Medicine & health




Maria Stein

Date Deposited:

16 May 2019 15:53

Last Modified:

29 Mar 2023 23:36




Actions (login required)

Edit item Edit item
Provide Feedback