Polycystic Kidney-like Disease in a Red-ear Slider Turtle (Trachemys scripta elegans).

Tecilla, M; Bielli, M; Origgi, Francesco (2018). Polycystic Kidney-like Disease in a Red-ear Slider Turtle (Trachemys scripta elegans). Journal of comparative pathology, 164, pp. 44-47. Elsevier 10.1016/j.jcpa.2018.08.006

[img] Text
1-s2.0-S0021997518300343-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (844kB) | Request a copy

A 14-year-old red-ear slider turtle (Trachemys scripta elegans) with no history of pre-existing clinical disease died and was referred for necropsy examination. Grossly, oesophageal prolapse, bilateral renal cysts and a paraduodenal cystic mass were detected. Tissues were processed routinely for histology and immunohistochemistry (IHC) with primary antibodies specific for Wilm's tumour suppressor gene-1 (WT-1), insulin, glucagon and pancytokeratins. Microscopically, renal medullary cysts and medullary atrophy resembled the changes associated with polycystic kidney disease (PKD). The cysts of the paraduodenal mass were lined by ciliated epithelial cells resembling embryonal cells and were intensely positive for glucagon and insulin by IHC. There was no cytokeratin expression in either lesion. WT-1 expression in the paraduodenal mass was cytoplasmic and appeared non-specific. Lesions were consistent with renal PKD-like disease and a pancreatic cystic hamartoma.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Origgi, Francesco

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0021-9975

Publisher:

Elsevier

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

29 May 2019 14:21

Last Modified:

05 Nov 2019 01:56

Publisher DOI:

10.1016/j.jcpa.2018.08.006

PubMed ID:

30360912

Uncontrolled Keywords:

kidney pancreas polycystic kidney-like disease turtle

BORIS DOI:

10.7892/boris.129636

URI:

https://boris.unibe.ch/id/eprint/129636

Actions (login required)

Edit item Edit item
Provide Feedback