Human "TH9" cells are a subpopulation of PPAR-γ+ TH2 cells.

Micossé, Claire; von Meyenn, Karl-Leonhard; Steck, Oliver; Kipfer, Enja; Adam, Christian; Simillion, Cedric; Jafari, Morteza; Olah, Peter; Yawalkar, Nikhil; Simon, Dagmar; Borradori, Luca; Kuchen, Stefan; Yerly, Daniel; Homey, Bernhard; Conrad, Curdin; Snijder, Berend; Schmidt, Marc; Schlapbach, Christoph (2019). Human "TH9" cells are a subpopulation of PPAR-γ+ TH2 cells. Science immunology, 4(31) American Association for the Advancement of Science 10.1126/sciimmunol.aat5943

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Although T1, T2, and T17 cells are well-defined T cell lineages in humans, it remains debated whether IL-9-producing T cells represent a bona fide "T9" lineage. Our understanding of the cellular characteristics and functions of IL-9-producing T cells in humans is still nascent. Here, we report that human IL-9-producing T cells express the chemokine receptors CCR4 and CCR8, produce high levels of IL-5 and IL-13, and express T2 lineage-associated transcription factors. In these cells, IL-9 production is activation dependent, transient, and accompanied by down-regulation of T2 cytokines, leading to an apparent "T9" phenotype. IL-9 T2 cells can be distinguished from "conventional" T2 cells based on their expression of the transcription factor PPAR-γ. Accordingly, PPAR-γ is induced in naïve T cells by priming with IL-4 and TGF-β ("T9" priming) and is required for IL-9 production. In line with their identity as early activated T2 cells, IL-9 T2 cells are found in acute allergic skin inflammation in humans. We propose that IL-9-producing T cells are a phenotypically and functionally distinct subpopulation of T2 cells that depend on PPAR-γ for full effector functions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Micossé, Claire; von Meyenn, Karl-Leonhard; Jafari, Morteza; Yawalkar, Nikhil; Simon, Dagmar; Borradori, Luca; Kuchen, Stefan and Schlapbach, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2470-9468

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

25 Jun 2019 14:19

Last Modified:

25 Jun 2019 14:19

Publisher DOI:

10.1126/sciimmunol.aat5943

PubMed ID:

30658968

URI:

https://boris.unibe.ch/id/eprint/129869

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