Association between perinatal interventional activity and 2-year outcome of Swiss extremely preterm born infants: a population-based cohort study.

Adams, Mark; Berger, Thomas M; Borradori-Tolsa, Cristina; Bickle-Graz, Myriam; Grunt, Sebastian; Gerull, Roland; Bassler, Dirk; Natalucci, Giancarlo (2019). Association between perinatal interventional activity and 2-year outcome of Swiss extremely preterm born infants: a population-based cohort study. BMJ open, 9(3), e024560. BMJ Publishing Group 10.1136/bmjopen-2018-024560

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OBJECTIVES

To investigate if centre-specific levels of perinatal interventional activity were associated with neonatal and neurodevelopmental outcome at 2 years of age in two separately analysed cohorts of infants: cohort A born at 22-25 and cohort B born at 26-27 gestational weeks, respectively.

DESIGN

Geographically defined, retrospective cohort study.

SETTING

All nine level III perinatal centres (neonatal intensive care units and affiliated obstetrical services) in Switzerland.

PATIENTS

All live-born infants in Switzerland in 2006-2013 below 28 gestational weeks, excluding infants with major congenital malformation.

OUTCOME MEASURES

Outcomes at 2 years corrected for prematurity were mortality, survival with any major neonatal morbidity and with severe-to-moderate neurodevelopmental impairment (NDI).

RESULTS

Cohort A associated birth in a centre with high perinatal activity with low mortality adjusted OR (aOR 0.22; 95% CI 0.16 to 0.32), while no association was observed with survival with major morbidity (aOR 0.74; 95% CI 0.46 to 1.19) and with NDI (aOR 0.97; 95% CI 0.46 to 2.02). Median age at death (8 vs 4 days) and length of stay (100 vs 73 days) were higher in high than in low activity centres. The results for cohort B mirrored those for cohort A.

CONCLUSIONS

Centres with high perinatal activity in Switzerland have a significantly lower risk for mortality while having comparable outcomes among survivors. This confirms the results of other studies but in a geographically defined area applying a more restrictive approach to initiation of perinatal intensive care than previous studies. The study adds that infants up to 28 weeks benefited from a higher perinatal activity and why further research is required to better estimate the added burden on children who ultimately do not survive.

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5 Citations in Web of Science ®
6 Citations in Scopus

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