Single-breath washout and association with structural lung disease in children with cystic fibrosis.

Yammine, Sophie; Ramsey, Kathryn A.; Skoric, Billy; King, Louise; Latzin, Philipp; Rosenow, Tim; Hall, Graham L; Ranganathan, Sarath C (2019). Single-breath washout and association with structural lung disease in children with cystic fibrosis. Pediatric pulmonology, 54(5), pp. 587-594. Wiley-Blackwell 10.1002/ppul.24271

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BACKGROUND In children with cystic fibrosis (CF) lung clearance index (LCI) from multiple-breath washout (MBW) correlates with structural lung disease. As a shorter test, single-breath washout (SBW) represents an attractive alternative to assess the ventilation distribution, however, data for the correlation with lung imaging are lacking. METHODS We assessed correlations between phase III slope (SIII) of double-tracer gas SBW, nitrogen MBW indices (LCI and moment ratios for overall ventilation distribution, Scond, and Sacin for conductive and mainly acinar ventilation, respectively) and structural lung disease assessed by chest computed tomography (CT) in children with CF. RESULTS In a prospective cross-sectional study data from MBW, SBW, and chest CT were obtained in 32 children with CF with a median (range) age of 8.2 (5.2-16.3) years. Bronchiectasis was present in 24 (75%) children and air trapping was present in 29 (91%). Median (IQR) SIII of SBW was -138.4 (150.6) mg/mol. We found no association between SIII with either the MBW outcomes or CT scores (n = 23, association with bronchiectasis extent r = 0.10, P = 0.64). LCI and Scond were associated with bronchiectasis extent (n = 23, r = 0.57, P = 0.004; r = 0.60, P = 0.003, respectively). CONCLUSIONS Acinar ventilation inhomogeneity measured by SBW was not associated with structural lung disease on CT. Double-tracer SBW added no benefit to indices measured by MBW.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Yammine, Sophie; Ramsey, Kathryn Angela and Latzin, Philipp


600 Technology > 610 Medicine & health








Romy Melanie Rodriguez Del Rio

Date Deposited:

14 Jan 2020 15:28

Last Modified:

14 Jan 2020 15:28

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PubMed ID:


Uncontrolled Keywords:

cystic fibrosis lung function lung imaging single-breath washout




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