Combining Pharmacological and Nonpharmacological Interventions in Network Meta-analysis in Psychiatry.

Del Giovane, Cinzia; Cortese, Samuele; Cipriani, Andrea (2019). Combining Pharmacological and Nonpharmacological Interventions in Network Meta-analysis in Psychiatry. JAMA psychiatry, 76(8), pp. 867-8. American Medical Association 10.1001/jamapsychiatry.2019.0574

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Network meta-analyses (NMAs) assess the comparative associations of 2 or more interventions even if they have not been compared in a randomized clinical trial. The validity of NMAs is founded on the assumption of transitivity (ie,that effect modifiers do not substantially differ across the included trials). The popularity of NMAs on pharmacological or nonpharmacological interventions is increasing in psychiatry. Recent NMAs have combined pharmacologicalandnonpharmacologicinterventions inthesamenetwork. Although this may be informative for developing guidelines, it is methodologically challenging and could compromise the validity of NMAs.We aimed to evaluate NMAs that combined pharmacological and nonpharmacological interventions and provide guidance on how to conduct them.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)

UniBE Contributor:

Del Giovane, Cinzia

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2168-622X

Publisher:

American Medical Association

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

23 Apr 2019 09:41

Last Modified:

12 Dec 2019 05:14

Publisher DOI:

10.1001/jamapsychiatry.2019.0574

PubMed ID:

30994881

BORIS DOI:

10.7892/boris.130261

URI:

https://boris.unibe.ch/id/eprint/130261

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