Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

Fiorito, Giovanni; McCrory, Cathal; Robinson, Oliver; Carmeli, Cristian; Rosales, Carolina Ochoa; Zhang, Yan; Colicino, Elena; Dugué, Pierre-Antoine; Artaud, Fanny; McKay, Gareth J; Jeong, Ayoung; Mishra, Pashupati P; Nøst, Therese H; Krogh, Vittorio; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Palli, Domenico; Matullo, Giuseppe; Guarrera, Simonetta; ... (2019). Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis. Aging, 11(7), pp. 2045-2070. Impact Journals 10.18632/aging.101900

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Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries.The four biological aging biomarkers were associated with education and different sets of risk factors independently, and the magnitude of the effects differed depending on the biomarker and the predictor. On average, the effect of low education on epigenetic aging was comparable with those of other lifestyle-related risk factors (obesity, alcohol intake), with the exception of smoking, which had a significantly stronger effect.Our study shows that low education is an independent predictor of accelerated biological (epigenetic) aging and that epigenetic clocks appear to be good candidates for disentangling the biological pathways underlying social inequalities in healthy aging and longevity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Muka, Taulant

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1945-4589

Publisher:

Impact Journals

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

08 May 2019 11:55

Last Modified:

24 Oct 2019 14:23

Publisher DOI:

10.18632/aging.101900

PubMed ID:

31009935

Uncontrolled Keywords:

biological aging education epigenetic clocks socioeconomic position

BORIS DOI:

10.7892/boris.130392

URI:

https://boris.unibe.ch/id/eprint/130392

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