Improved survival rates of AML patients following admission to the intensive care unit.

Fassbind, Priska; Jeker, Barbara; Müller, Beatrice Ursula; Bacher, Vera Ulrike; Zimmerli, Stefan; Endrich, Olga; Gahl, Brigitta; Novak, Urban; Pabst Müller, Thomas Niklaus (2019). Improved survival rates of AML patients following admission to the intensive care unit. Leukemia & lymphoma, 60(10), pp. 2423-2431. Taylor & Francis 10.1080/10428194.2019.1594213

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Induction chemotherapy in AML patients may have life-threatening side effects requiring intensive care unit (ICU) treatment. We analyzed all AML patients receiving intensive chemotherapy at a single academic center between 01/2006-12/2016. At least one ICU admission was observed in 32% (76/240) patients, and 33% of those died following ICU admission. Whereas the ICU admission proportion remained stable, mortality after ICU admission decreased from 14% (2006-2008) to 3% (2014-2016; p = .056). The number of failing organ systems inversely correlated with surviving ICU admission (p < .001). Sepsis and renal, cardiac and pulmonary failure were each associated with higher mortality. With increasing ICU duration, survival probability decreased (p < .001), but remained >50% even after 14 days of ICU treatment. Progression-free and overall survival were comparable between ICU surviving patients and patients never needing ICU support. In conclusion, outcome after ICU admission of AML patients has substantially improved in recent years.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Jeker, Barbara; Bacher, Vera Ulrike; Zimmerli, Stefan; Gahl, Brigitta; Novak, Urban and Pabst Müller, Thomas Niklaus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1029-2403

Publisher:

Taylor & Francis

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

15 Jul 2019 11:02

Last Modified:

16 Oct 2019 01:31

Publisher DOI:

10.1080/10428194.2019.1594213

PubMed ID:

30943056

Uncontrolled Keywords:

AML ICU intensive care intensive treatment outcome prognosis survival

URI:

https://boris.unibe.ch/id/eprint/130450

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