The novel adipokine CTRP1 is significantly associated with the incidence of major adverse cardiovascular events.

Muendlein, Axel; Leiherer, Andreas; Saely, Christoph; Ebner, Janine; Geiger, Kathrin; Brandtner, Eva Maria; Vonbank, Alexander; Fraunberger, Peter; Drexel, Heinz (2019). The novel adipokine CTRP1 is significantly associated with the incidence of major adverse cardiovascular events. Atherosclerosis, 286, pp. 1-6. Elsevier 10.1016/j.atherosclerosis.2019.04.222

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BACKGROUND AND AIMS The recently identified adiponectin paralogue C1q and tumor necrosis factor-related protein 1 (CTRP1) has been associated with obesity-linked disorders and coronary atherosclerosis. So far, the impact of circulating CTRP1 on the incidence of future cardiovascular events is unclear. Therefore, we aimed at investigating the association between CTRP1 and future cardiovascular risk. METHODS We measured CTRP1 serum levels in 539 patients undergoing coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Prospectively, we recorded major adverse cardiovascular events (MACE), defined as the incidence of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke over a follow-up period of 8 years. RESULTS At baseline, obesity, the metabolic syndrome, type 2 diabetes, and non-alcoholic fatty liver disease were significantly associated with increased CTRP1 (all p-values ≤0.001). Prospectively, MACE rates were lowest in the first quartile (15.3%) and increased over the second (23.7%) to the third and fourth quartile (each 29.0%; p = 0.008). Moreover, after multivariable adjustment, CTRP1 was significantly associated with future MACE, with adjusted HRs of 1.83 [1.04-3.23]; p=0.037, 2.16 [1.25-3.75]; p=0.006, and 1.80 [1.03-3.15]; p=0.038, for CTRP1 quartiles two, three and four, respectively, when compared to quartile one. CONCLUSIONS We conclude that high serum levels of CTRP1 are significantly associated with future MACE.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Drexel, Heinz

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0021-9150

Publisher:

Elsevier

Language:

English

Submitter:

Isabel Lorenz

Date Deposited:

17 Jul 2019 15:14

Last Modified:

17 Jul 2019 15:14

Publisher DOI:

10.1016/j.atherosclerosis.2019.04.222

PubMed ID:

31051410

Uncontrolled Keywords:

Adipokine CTRP1 Major adverse cardiovascular events Prospective study Risk factor

BORIS DOI:

10.7892/boris.130562

URI:

https://boris.unibe.ch/id/eprint/130562

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