A Bacterial Growth Law out of Steady State.

Korem Kohanim, Yael; Levi, Dikla; Jona, Ghil; Towbin, Benjamin D.; Bren, Anat; Alon, Uri (2018). A Bacterial Growth Law out of Steady State. Cell reports, 23(10), pp. 2891-2900. Cell Press 10.1016/j.celrep.2018.05.007

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Bacterial growth follows simple laws in constant conditions. However, bacteria in nature often face fluctuating environments. We therefore ask whether there are growth laws that apply to changing environments. We derive a law for upshifts using an optimal resource-allocation model: the post-shift growth rate equals the geometrical mean of the pre-shift growth rate and the growth rate on saturating carbon. We test this using chemostat and batch culture experiments, as well as previous data from several species. The increase in growth rate after an upshift indicates that ribosomes have spare capacity (SC). We demonstrate theoretically that SC has the cost of slow steady-state growth but is beneficial after an upshift because it prevents large overshoots in intracellular metabolites and allows rapid response to change. We also provide predictions for downshifts. The present study quantifies the optimal degree of SC, which rises the slower the growth rate, and suggests that SC can be precisely regulated.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Towbin, Benjamin Daniel

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

2211-1247

Publisher:

Cell Press

Language:

English

Submitter:

Benjamin Daniel Towbin

Date Deposited:

14 Jan 2021 08:45

Last Modified:

05 Dec 2022 15:28

Publisher DOI:

10.1016/j.celrep.2018.05.007

PubMed ID:

29874577

Uncontrolled Keywords:

bacterial growth laws biological physics cellular regulation non-equilibrium nutritional shifts optimality quantitative evolutionary design resource allocation safety factors systems biology

BORIS DOI:

10.48350/130601

URI:

https://boris.unibe.ch/id/eprint/130601

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