Mechanisms of heterochromatin subnuclear localization.

Towbin, Benjamin D; Gonzalez-Sandoval, Adriana; Gasser, Susan M (2013). Mechanisms of heterochromatin subnuclear localization. Trends in biochemical sciences, 38(7), pp. 356-363. Elsevier 10.1016/j.tibs.2013.04.004

Text 1-s2.0-S096800041300073X-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (759kB) | Request a copy

Transcriptionally repressed heterochromatin becomes the dominant form of chromatin in most terminally differentiated cells. Moreover, in most cells, at least one class of heterochromatin is positioned adjacent to the nuclear lamina. Recent approaches have addressed the mechanism of heterochromatin localization, in order to determine whether spatial segregation contributes to gene repression. Findings in worms and human cells confirm a role for histone H3K9 methylation in heterochromatin positioning, identifying a modification that is also necessary for gene repression of worm transgenic arrays. These pathways appear to be conserved, although mutations in mammalian cells have weaker effects, possibly due to redundancy in positioning mechanisms. We propose a general model in which perinuclear anchoring is linked to an epigenetic propagation of the heterochromatic state, through histone modification.

Interest & Impact

Downloads

1 since deposited on 08 Jan 2021
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item