Gonzalez-Sandoval, Adriana; Towbin, Benjamin D; Gasser, Susan M (2013). The formation and sequestration of heterochromatin during development: delivered on 7 September 2012 at the 37th FEBS Congress in Sevilla, Spain. The FEBS journal, 280(14), pp. 3212-3219. FEBS Press 10.1111/febs.12319
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Chromatin is not randomly positioned in the nucleus, but is distributed in subdomains based on its degree of compaction and transcriptional status. Recent studies have shed light on the logic of chromatin distribution, showing that tissue-specific promoters drive distinct patterns of gene positioning during cell-type differentiation. In addition, the sequestration of heterochromatin at the nuclear envelope has been found to depend on lamin and lamin-associated proteins. On the chromatin side, H3K9 monomethylation, dimethylation and trimethylation were shown to be the critical signals for perinuclear anchoring in worm embryonic nuclei. Downregulation of an equivalent histone methyltransferase, G9a, in human cells has a similar effect. In worms, the sequestration of the terminal methyltransferase by repressed chromatin may facilitate the propagation of a heterochromatin compartment, much as the sequestration of the silent information regulatory complex does at telomeric foci in budding yeast. These results argue for conserved logic in eukaryotic nuclear organization.
Item Type: |
Journal Article (Original Article) |
---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology |
UniBE Contributor: |
Towbin, Benjamin Daniel |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
1742-4658 |
Publisher: |
FEBS Press |
Language: |
English |
Submitter: |
Benjamin Daniel Towbin |
Date Deposited: |
08 Jan 2021 15:00 |
Last Modified: |
05 Dec 2022 15:28 |
Publisher DOI: |
10.1111/febs.12319 |
PubMed ID: |
23648132 |
Uncontrolled Keywords: |
C. elegans H3K9 methylation heterochromatin nuclear periphery |
BORIS DOI: |
10.48350/130608 |
URI: |
https://boris.unibe.ch/id/eprint/130608 |