Properdin in childhood and its association with wheezing and atopy

Staley, Kathryn Grace; Kuehni, Claudia Elisabeth; Strippoli, Marie-Pierre Françoise; McNally, Teresa; Silverman, Michael; Stover, Cordula (2010). Properdin in childhood and its association with wheezing and atopy. Pediatric allergy and immunology, 21(4), e787-e791. Oxford: Wiley-Blackwell 10.1111/j.1399-3038.2009.00979.x

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Properdin, a serum glycoprotein, is an important component of innate immunity, the only known positive regulator of complement, acting as an initiation point for alternative pathway activation. As an X-linked protein, we hypothesized that properdin may play a modulatory role in the pathogenesis of viral wheeze in children, which tends to be more common and more severe in boys. We aimed to determine properdin levels in a community-based paediatric sample, and to assess whether levels of properdin were associated with childhood wheeze phenotypes and atopy. We studied 137 school-children aged 8-12 yrs, a nested sample from a cohort study. Properdin was measured by a commercial enzyme-linked immunoabsorbant assay. We assessed wheeze by questionnaire, validated it by a nurse-led interview and performed skin prick tests and a methacholine challenge in all children. Forty children (29%) reported current wheeze. Serum properdin levels ranged between 18 and 40 microg/ml. Properdin was not associated with age, gender, atopy, bronchial responsiveness, current wheeze (neither the viral wheeze nor multiple-trigger wheeze phenotype) or severity of wheeze, but was slightly lower in south Asian (median 21.8 microg/ml) compared with white children (23.3 microg/ml; p = 0.006). Our data make it unlikely that properdin deficiency is common in healthy children or that levels of properdin are a major risk factor for wheeze or atopy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Kühni, Claudia and Strippoli, Marie-Pierre

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0905-6157

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

11 Sep 2017 19:58

Publisher DOI:

10.1111/j.1399-3038.2009.00979.x

PubMed ID:

20337960

Web of Science ID:

000285997600019

BORIS DOI:

10.7892/boris.1307

URI:

https://boris.unibe.ch/id/eprint/1307 (FactScience: 202695)

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