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n
q
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W
n
q
496.686 677.31 41.839 -41.896 re
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n
/GS2 gs
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0.347 w
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h
S
Q
Q
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EMC
EMC
1 0 0 1 -527.19702 -641.08899 cm
0.075 0.078 0.075 sc
BT
/T1_1 1 Tf
22.7999 0 0 24.0001 56.6929 651.28802 Tm
[ (Pneumolysin) -303 (and) -299 (the) -302 (bacterial) -303 (capsule) -303 (of) ] TJ
1.084 TL
/T1_2 1 Tf
22.7999 0 0 24.0001 56.6929 625.27192 Tm
[ (Streptococcus) -308 (pneumoniae) ] TJ
/T1_1 1 Tf
22.7999 0 0 24.0001 312.09737 625.27192 Tm
[ (cooperatively) ] TJ
22.7999 0 0 24.0001 56.6929 599.30381 Tm
[ (inhibit) -301 (taxis) -303 (and) -299 (motility) -306 (of) -299 (microglia) ] TJ
/T1_3 1 Tf
10.4499 0 0 11.0001 56.6929 575.26282 Tm
[ (Sabrina) -305 (Hupp) ] TJ
7.8372 0 0 7.3327 113.726 580.19513 Tm
[ (1) ] TJ
10.4499 0 0 11.0001 117.4677 575.26282 Tm
[ (\054) -301 (Denis) -301 (Grandgirard) ] TJ
7.8372 0 0 7.3327 198.4252 580.19513 Tm
[ (2) ] TJ
10.4499 0 0 11.0001 202.1669 575.26282 Tm
[ (\054) -301 (Timothy) -302 (J\056) -299 (Mitchell) ] TJ
7.8372 0 0 7.3327 285.78891 580.19513 Tm
[ (3) ] TJ
10.4499 0 0 11.0001 289.53061 575.26282 Tm
[ (\054) -301 (Stephen) -303 (L\056) -304 (Leib) ] TJ
7.8372 0 0 7.3327 359.37631 580.19513 Tm
[ (2) ] TJ
10.4499 0 0 11.0001 363.11801 575.26282 Tm
[ (\054) -301 (Lucy) -302 (J\056) -305 (Hathaway) ] TJ
7.8372 0 0 7.3327 440.2204 580.19513 Tm
[ (2) ] TJ
10.4499 0 0 11.0001 447.1369 575.26282 Tm
[ (and) ] TJ
10.4499 0 0 11.0001 56.69731 561.25969 Tm
[ (Asparouh) -304 (I\056) -299 (Iliev) ] TJ
7.8372 0 0 7.3327 122.9669 566.19202 Tm
[ (1\052) ] TJ
ET
/EmbeddedDocument /MC2 BDC
/Document /MC3 BDC
q
129.713 568.46002 8.787 -8.787 re
W
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h
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f
EMC
EMC
1 0 0 1 -132.60001 -566.49896 cm
0.075 0.078 0.075 sc
BT
/T1_0 1 Tf
10.3 0 0 10.3 63.2126 522.7652 Tm
[ (Abstract) ] TJ
/T1_4 1 Tf
10.0001 0 0 10.0001 63.2126 504.79361 Tm
[ (Background\072) ] TJ
/T1_5 1 Tf
10.0001 0 0 10.0001 120.64318 504.79361 Tm
[ (Streptococcus) -307 (pneumonia) -9 (e) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 227.96425 504.79361 Tm
[ (is) -301 (the) -304 (cause) -304 (of) -303 (a) -301 (highly) -305 (lethal) -302 (form) -300 (of) -303 (menin) -7 (gitis) -299 (in) -304 (humans\056) -308 (Microglial) ] TJ
10.0001 0 0 10.0001 63.2126 492.77349 Tm
[ (cells) -300 (in) -304 (the) -298 (br) -7 (ain) -299 (represent) -308 (the) -304 (first) -304 (line) -297 (of) -303 (defense) -308 (against) -306 (pathogens\054) -307 (and) -301 (th) -6 (ey) -297 (partici) -9 (pate) -300 (in) -304 (the) -298 (inflamm) -10 (atory) ] TJ
1.202 TL
10.0001 0 0 10.0001 63.2126 480.75337 Tm
[ (response\056) -308 (The) -301 (cholesterol\055d) -11 (ependent) -307 (cytolysin) -304 (pneumolys) -10 (in) -298 (and) -306 (the) -298 (bacter) -9 (ial) -299 (capsule) -309 (are) -302 (key) -301 (pathogeni) -11 (c) -300 (factors\054) ] TJ
1.196 TL
10.0001 0 0 10.0001 63.2126 468.79325 Tm
[ (known) -300 (to) -301 (exa) -8 (cerbate) -301 (th) -6 (e) -298 (course) -303 (of) -303 (pneum) -8 (ococcal) -306 (meningitis\056) ] TJ
1.502 TL
/T1_4 1 Tf
10.0001 0 0 10.0001 63.2126 453.7731 Tm
[ (Methods\072) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 106.41303 453.7731 Tm
[ (We) -302 (utilize) -10 (d) -298 (live) -302 (imaging) -306 (and) -306 (immunostaining) -308 (of) -303 (glial) -304 (cells) -305 (in) -298 (dissociat) -11 (ed) -301 (and) -301 (acute) -304 (br) -7 (ain) -299 (slice) -305 (cultures) -303 (to) ] TJ
10.0001 0 0 10.0001 63.2126 441.81298 Tm
[ (study) -302 (the) -304 (effect) -300 (of) -303 (pneum) -8 (ococcal) -306 (factors\054) -303 (including) -312 (the) -298 (choleste) -8 (rol\055dependen) -11 (t) -299 (cytolysin) -304 (pneum) -8 (olysin) -300 (and) -306 (the) ] TJ
1.202 TL
10.0001 0 0 10.0001 63.2126 429.79286 Tm
[ (pneumococcal) -308 (capsule\054) -308 (on) -304 (microglial) -304 (motil) -8 (ity) -300 (and) -301 (taxis\056) ] TJ
1.502 TL
/T1_4 1 Tf
10.0001 0 0 10.0001 63.2126 414.77271 Tm
[ (Results\072) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 99.15296 414.77271 Tm
[ (In) -298 (brain) -306 (tissue\054) -307 (primary) -307 (microglia) -308 (cells) -300 (showed) -306 (an) -303 (enhanc) -9 (ed) -301 (response) -303 (towards) -310 (lysates) -302 (from) -306 (bacteria) -306 (lackin) -9 (g) ] TJ
10.0001 0 0 10.0001 63.2126 402.81259 Tm
[ (capsules) -308 (and) -301 (pneumolys) -10 (in) -298 (as) -306 (they) -298 (moved) -308 (rapidly) -303 (to) -301 (are) -8 (as) -300 (with) -305 (an) -303 (abundance) -305 (of) -303 (bacterial) -308 (factors\056) -309 (The) -301 (presence) -305 (of) ] TJ
1.202 TL
10.0001 0 0 10.0001 63.2126 390.79247 Tm
[ (bacterial) -308 (capsules) -308 (and) -301 (pneumolys) -10 (in) -298 (cumula) -10 (tively) -300 (inhibited) -306 (microg) -9 (lial) -301 (taxis\056) -303 (In) -304 (mixed) -305 (cultures) -303 (of) -303 (astrocyte) -10 (s) -299 (and) ] TJ
10.0001 0 0 10.0001 63.2126 378.77235 Tm
[ (microglia\054) -307 (the) -304 (motility) -303 (of) -303 (microglia) -308 (was) -302 (inhibited) -306 (by) -303 (capsular) -305 (comp) -9 (onents) -301 (within) -303 (minut) -8 (es) -302 (after) -302 (exposure\056) -307 (The) ] TJ
1.196 TL
10.0001 0 0 10.0001 63.2126 366.81223 Tm
[ (reduced) -306 (motility) -303 (was) -302 (par) -8 (tially) -305 (reversed) -303 (by) -303 (mannan\054) -305 (a) -301 (mann) -9 (ose) -298 (receptor) -306 (inhi) -7 (bitor\056) -302 (The) -301 (effects) -305 (on) -304 (microglia) -308 (were) -301 (not) ] TJ
1.202 TL
10.0001 0 0 10.0001 63.2126 354.79211 Tm
[ (mediated) -307 (by) -298 (astro) -10 (cytes) -300 (because) -310 (pure) -301 (microg) -9 (lial) -301 (cells) -305 (responded) -305 (to) -301 (various) -310 (pneumococca) -12 (l) -297 (lysates) -307 (similarly) -309 (with) ] TJ
10.0001 0 0 10.0001 63.2126 342.77199 Tm
[ (distinct) -304 (cell) -301 (shape) -308 (changes) -304 (as) -300 (seen) -307 (in) -298 (mixed) -305 (cultures\056) ] TJ
1.497 TL
/T1_4 1 Tf
10.0001 0 0 10.0001 63.2126 327.80184 Tm
[ (Conclusions\072) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 120.30317 327.80184 Tm
[ (Our) -303 (data) -304 (indicate) -305 (tha) -7 (t) -299 (microglia) -308 (possess) -304 (the) -304 (capacity) -304 (for) -307 (a) -301 (very) -302 (agile) -305 (response) -303 (toward) -10 (s) -299 (bacterial) ] TJ
10.0001 0 0 10.0001 63.2126 315.78172 Tm
[ (pathogens\054) -307 (but) -304 (key) -301 (pathogeni) -11 (c) -300 (factors\054) -303 (such) -308 (as) -300 (pneum) -8 (ococcal) -306 (capsules) -308 (and) -301 (pneumolys) -10 (in\054) -303 (inhibited) -306 (this) -301 (response) ] TJ
1.202 TL
10.0001 0 0 10.0001 63.2126 303.7616 Tm
[ (shortly) -301 (after) -307 (a) -301 (bacterial) -308 (challenge\056) -304 (Furthermor) -12 (e\054) -302 (we) -300 (demonstr) -10 (ate) -297 (for) -307 (the) -298 (first) -304 (time) -302 (that) -306 (the) -298 (bacter) -9 (ial) -299 (capsu) -10 (le) -299 (affects) ] TJ
1.196 TL
10.0001 0 0 10.0001 63.2126 291.80148 Tm
[ (cellular) -303 (behavior) -12 (s) -299 (such) -302 (as) -300 (motil) -8 (ity) -300 (and) -301 (taxis\056) ] TJ
1.701 TL
/T1_4 1 Tf
10.0001 0 0 10.0001 63.2126 274.79131 Tm
[ (Keywords\072) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 110.83308 274.79131 Tm
[ (Microglia\054) -309 (Bacterial) -304 (capsu) -10 (le\054) -298 (Pneumolys) -12 (in\054) ] TJ
/T1_5 1 Tf
10.0001 0 0 10.0001 278.92476 274.79131 Tm
[ (Streptococcus) -307 (pneumonia) -9 (e) ] TJ
/T1_3 1 Tf
10.0001 0 0 10.0001 383.2358 274.79131 Tm
[ (\054) -299 (M) -7 (eningitis) ] TJ
/T1_0 1 Tf
10.3 0 0 10.3 56.6929 244.34641 Tm
[ (Backgroun) -14 (d) ] TJ
/T1_6 1 Tf
9.7999 0 0 9.7999 56.6929 232.3275 Tm
[ (B) -14 (acterial) -426 (men) -8 (ingitis) -427 (is) -419 (a) -426 (disea) -13 (se) -423 (with) -425 (high) -429 (lethality) -431 (and) ] TJ
1.226 TL
9.7999 0 0 9.7999 56.6929 220.31282 Tm
[ (substan) -12 (tial) -655 (disability) -658 (of) -653 (sur) -35 (vivin) -8 (g) -649 (patien) -10 (t) -13 (s) -650 (\133) ] TJ
0 0 1 sc
9.7999 0 0 9.7999 249.22174 220.31282 Tm
[ (1) ] TJ
0.075 0.078 0.075 sc
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