Sperm analysis of patients after successful treatment of childhood acute lymphoblastic leukemia with chemotherapy

Marquis, Adine; Kuehni, Claudia E; Strippoli, Marie-Pierre F; Kühne, Thomas; Brazzola, Pierluigi (2010). Sperm analysis of patients after successful treatment of childhood acute lymphoblastic leukemia with chemotherapy. Pediatric blood & cancer, 55(1), pp. 208-210. Hoboken, N.J.: Wiley-Liss 10.1002/pbc.22475

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Survivors of childhood acute lymphoblastic leukemia (ALL) treated with radiotherapy are at risk for impaired fertility. Whether chemotherapy alone is also long-term gonadotoxic is unclear. We assessed gonadal function in 11 male ALL-survivors treated with the same chemotherapy regimen and compared sperm analysis to healthy men. While sex hormone levels were normal in all subjects, 5/11 survivors showed pathological sperm concentration and 4/11 a decreased total sperm count compared to WHO criteria. Compared to healthy controls, all quantitative parameters in semen analysis of survivors were decreased. This suggests that treatment with chemotherapeutic agents alone, even in moderate doses, might have a gonadotoxic effect.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Marquis, Adine; Kühni, Claudia and Strippoli, Marie-Pierre

ISSN:

1545-5009

Publisher:

Wiley-Liss

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

11 Sep 2017 14:41

Publisher DOI:

10.1002/pbc.22475

PubMed ID:

20310003

Web of Science ID:

000278032700048

BORIS DOI:

10.7892/boris.1308

URI:

https://boris.unibe.ch/id/eprint/1308 (FactScience: 202696)

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