The Expression and Possible Functions of Tenascin-W During Development and Disease.

Tucker, Richard P; Degen, Martin (2019). The Expression and Possible Functions of Tenascin-W During Development and Disease. Frontiers in cell and developmental biology, 7(53), p. 53. Frontiers 10.3389/fcell.2019.00053

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Tenascins are a family of multifunctional glycoproteins found in the extracellular matrix of chordates. Two of the tenascins, tenascin-C and tenascin-W, form hexabrachions. In this review, we describe the discovery and domain architecture of tenascin-W, its evolution and patterns of expression during embryogenesis and in tumors, and its effects on cells in culture. In avian and mammalian embryos tenascin-W is primarily expressed at sites of osteogenesis, and in the adult tenascin-W is abundant in certain stem cell niches. In primary cultures of osteoblasts tenascin-W promotes cell migration, the formation of mineralized foci and increases alkaline phosphatase activity. Tenascin-W is also prominent in many solid tumors, yet it is missing from the extracellular matrix of most adult tissues. This makes it a potential candidate for use as a marker of tumor stroma and a target for anti-cancer therapies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Orthodontic Research

UniBE Contributor:

Degen, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2296-634X

Publisher:

Frontiers

Language:

English

Submitter:

Renate Imhof-Etter

Date Deposited:

19 Jul 2019 06:43

Last Modified:

23 Oct 2019 15:50

Publisher DOI:

10.3389/fcell.2019.00053

PubMed ID:

31032255

Uncontrolled Keywords:

development extracellular matrix osteogenesis stem cells tenascin-W tumor stroma

BORIS DOI:

10.7892/boris.130808

URI:

https://boris.unibe.ch/id/eprint/130808

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