Non-volatile particle emissions from Aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells

Jonsdottir, Hulda Run; Delaval, Mathilde; Leni, Zaira; Keller, Anita; Brem, Benjamin T.; Siegrist, Frithjof; Schönenberger, David; Durdina, Lukas; Elser, Mirjam; Burtscher, Heinz; Liati, Anthi; Geiser, Marianne (2019). Non-volatile particle emissions from Aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells. Communications biology, 2(90), p. 90. Springer Nature 10.1038/s42003-019-0332-7

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Aircraft emissions contribute to local and global air pollution. Health effects of particulate matter (PM) from aircraft engines are largely unknown, since controlled cell exposures at relevant conditions are challenging. We examined the toxicity of non-volatile PM (nvPM) emissions from a CFM56-7B26 turbofan, the world’s most used aircraft turbine using an unprecedented exposure setup. We combined direct turbine-exhaust sampling under realistic engine operating conditions and the Nano-Aerosol Chamber for In vitro Toxicity to deposit particles onto air–liquid-interface cultures of human bronchial epithelial cells (BEAS-2B) at physiological conditions. We evaluated acute cellular responses after 1-h exposures to diluted exhaust from conventional or alternative fuel combustion. We show that single, short-term exposures to nvPM impair bronchial epithelial cells, and PM from conventional fuel at ground-idle conditions is the most hazardous. Electron microscopy of soot reveals varying reactivity matching the observed cellular responses. Stronger responses at lower mass concentrations suggest that additional metrics are necessary to evaluate health risks of this increasingly important emission source.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Cell Biology

UniBE Contributor:

Jonsdottir, Hulda Run; Delaval, Mathilde; Leni, Zaira and Geiser, Marianne

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2399-3642

Publisher:

Springer Nature

Language:

English

Submitter:

Marianne Geiser Kamber

Date Deposited:

19 Jul 2019 06:50

Last Modified:

22 Oct 2019 19:35

Publisher DOI:

10.1038/s42003-019-0332-7

PubMed ID:

30854482

Additional Information:

Medienmitteilung Uni Bern (16. Mai 2019): https://tinyurl.com/FeinstaubTurbinen

BORIS DOI:

10.7892/boris.131172

URI:

https://boris.unibe.ch/id/eprint/131172

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