Evaluation of C-reactive protein and its kinetics as a prognostic indicator in canine leptospirosis.

Buser, F C; Schweighauser, A; Im Hof-Gut, M; Bigler, B; Marti, E; Mirkovitch, J; Francey, T (2019). Evaluation of C-reactive protein and its kinetics as a prognostic indicator in canine leptospirosis. Journal of small animal practice, 60(8), pp. 477-485. Pergamon Press 10.1111/jsap.13004

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OBJECTIVE To evaluate C-reactive protein at presentation and during hospitalisation in dogs with acute kidney injury resulting from leptospirosis to compare C-reactive protein at presentation in dogs with acute kidney injury of different aetiology and to study its correlation with markers of inflammation, azotaemia and survival. MATERIALS AND METHODS Prospective observational study of 41 dogs with acute kidney injury secondary to leptospirosis and 15 control dogs with acute kidney injury of different aetiology. C-reactive protein was measured at presentation in both groups and daily for 7 days in a subgroup of 28 dogs with leptospirosis. The associations of C-reactive protein with neutrophil count, albumin, urea, creatinine and survival were analysed. RESULTS C-reactive protein was increased at presentation in all dogs with leptospirosis but was not significantly different from dogs with acute kidney injury of different cause. It was associated with markers of inflammation (neutrophil count, albumin) but not with azotaemia (creatinine, urea). It decreased gradually from presentation to day 4, with significantly lower concentrations in survivors than non-survivors. Initial C-reactive protein was only weakly associated with outcome, but its average concentration from presentation to day 2 was more strongly associated. Absolute and relative changes in C-reactive protein during hospitalisation and creatinine at presentation were not associated with survival. CLINICAL SIGNIFICANCE Serial assessment of C-reactive protein may improve outcome prediction in dogs with leptospirosis compared with a single measurement at presentation or with markers of renal function.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Internal Medicine

UniBE Contributor:

Schweighauser, Ariane; Marti, Eliane Isabelle; Mirkovitch, Jelena and Francey, T

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

0022-4510

Publisher:

Pergamon Press

Language:

English

Submitter:

Thierry Francey-Spicher

Date Deposited:

06 Jun 2019 15:20

Last Modified:

24 Oct 2019 11:27

Publisher DOI:

10.1111/jsap.13004

PubMed ID:

31006872

BORIS DOI:

10.7892/boris.131201

URI:

https://boris.unibe.ch/id/eprint/131201

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