Bargiotas, Panagiotis; Dietmann, Anelia; Haynes, Alan G; Kallweit, Ulf; Garcia Calle, Marta; Schmidt, Markus; Mathis, Johannes; Bassetti, Claudio L (2019). The Swiss Narcolepsy Scale (SNS) and its short form (sSNS) for the discrimination of narcolepsy in patients with hypersomnolence: a cohort study based on the Bern Sleep-Wake Database. Journal of neurology, 266(9), pp. 2137-2143. Springer-Medizin-Verlag 10.1007/s00415-019-09365-2
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Previous studies reported high sensitivity and specificity of the Swiss Narcolepsy Scale (SNS) for the diagnosis of narcolepsy type 1. We used data from the Bern Sleep-Wake Database to investigate the discriminating capacity of both the SNS and the Epworth Sleepiness Scale (ESS) to identify narcolepsy type 1 and type 2 in patients with central disorders of hypersomnolence (CDH) or sleepy patients with obstructive sleep apnea (OSA). In addition, we aimed to develop a simplified version of the SNS. We created the two-item short-form SNS (sSNS), based on the discriminative capability of the models including all possible combinations of the five questions of the SNS. Using the previously published co-efficiencies, we confirmed the high capacity of the SNS in identifying narcolepsy type 1. The updated SNS (based on new co-efficiencies and cutoff) and the sSNS showed high capacity and were both superior to ESS in identifying narcolepsy type 1. The sSNS correlated significantly with the SNS (r = - 0.897, p < 0.001). No scale showed sufficient discrimination for narcolepsy type 2. This is the largest cohort study that confirms the discriminating power of SNS for narcolepsy type 1 in patients with hypersomnolence and the first study to assess its discriminative power for narcolepsy type 2. The easy-to-use and easy-to-calculate short-form scale has a high discriminating power for narcolepsy type 1 and may be used as screening tool, especially among general practitioners, to identify patients and accelerate their referral to a center of expertise.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR) |
UniBE Contributor: |
Bargiotas, Panagiotis, Dietmann, Anelia, Haynes, Alan, Kallweit, Ulf, Garcia Calle, Marta, Schmidt, Markus Helmut, Mathis, Johannes, Bassetti, Claudio L.A. |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0340-5354 |
Publisher: |
Springer-Medizin-Verlag |
Language: |
English |
Submitter: |
Doris Kopp Heim |
Date Deposited: |
06 Jun 2019 08:59 |
Last Modified: |
20 Feb 2024 14:16 |
Publisher DOI: |
10.1007/s00415-019-09365-2 |
PubMed ID: |
31127382 |
Uncontrolled Keywords: |
Excessive daytime sleepiness Hypersomnia Hypersomnolence Screening tool Validation |
BORIS DOI: |
10.7892/boris.131301 |
URI: |
https://boris.unibe.ch/id/eprint/131301 |
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