Identification of ureteral stones at reduced radiation exposure: a pilot study comparing conventional versus digital low-dosage linear slot scanning (Lodox) radiography.

Fiechter, Stefanie; Geissbühler, Elio; Bähler, Alexandrine; Obmann, Verena Carola; Meierhans, Susan; Exadaktylos, Aris K.; Christe, Andreas; Thalmann, George N.; Roth, Beat (2019). Identification of ureteral stones at reduced radiation exposure: a pilot study comparing conventional versus digital low-dosage linear slot scanning (Lodox) radiography. (In Press). World journal of urology Springer-Verlag 10.1007/s00345-019-02803-w

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PURPOSE Digital low-dosage, linear slot scanning radiography (Lodox) is an imaging modality that can emit down to one-tenth the radiation of conventional X-ray systems. We prospectively evaluated Lodox as a diagnostic imaging modality in patients with ureterolithiasis. METHODS Conventional kidney-ureter-bladder (KUB) X-ray and Lodox were performed in 41 patients presenting with acute flank pain due to unilateral ureteral stone confirmed by computed tomography. KUB X-ray and Lodox images were then reviewed by four blinded readers (urology expert/resident, radiology expert/resident). Identification rates were compared using Pearson's Chi square test. The impact of different parameters on stone identification by Lodox was evaluated using logistic regression and generalized linear mixed models. Inter-reader agreement was tested using Cohen's kappa coefficient. RESULTS Median stone size was 5 mm (range 2-12), median stone density was 800 HU (range 200-1500). The identification rates of the urology expert were 68% for KUB X-ray and 90% for Lodox (p = 0.014), and for all four readers 61% for KUB X-ray and 62% for Lodox (p = 0.8). Radiation exposure for KUB X-ray and Lodox was 0.45 mSv (SD ± 0.64) and 0.027 mSv (SD ± 0.038), respectively. Multivariable analyses showed an association between stone identification by Lodox and stone size (p < 0.001), stone density (p = 0.005), lower body mass index (p = 0.005), and reader (p < 0.001). CONCLUSIONS The high identification rates and low radiation doses of Lodox make it a promising imaging modality for the diagnosis of ureteral stones. Further validation in larger cohorts, including performance evaluation for renal stones, is warranted. TRIAL REGISTRATION http://www.controlled-trails.com/ISRCTN12915426 .

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Bähler, Alexandrine; Obmann, Verena Carola; Exadaktylos, Aristomenis; Christe, Andreas; Thalmann, George and Roth, Beat

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0724-4983

Publisher:

Springer-Verlag

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

17 Jul 2019 16:54

Last Modified:

17 Jul 2019 16:54

Publisher DOI:

10.1007/s00345-019-02803-w

PubMed ID:

31165230

Uncontrolled Keywords:

Imaging Lodox® Radiation exposure Urolithiasis

BORIS DOI:

10.7892/boris.131304

URI:

https://boris.unibe.ch/id/eprint/131304

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