Time course of lymphocyte repopulation after dimethyl fumarate-induced grade 3 lymphopenia: contribution of patient age.

Briner, Myriam; Bagnoud, Maud; Miclea, Andrei; Friedli, Christoph; Diem, Lara; Chan, Andrew; Hoepner, Robert; Salmen, Anke (2019). Time course of lymphocyte repopulation after dimethyl fumarate-induced grade 3 lymphopenia: contribution of patient age. Therapeutic advances in neurological disorders, 12, p. 1756286419843450. Sage 10.1177/1756286419843450

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Background Dimethyl fumarate (DMF) is licensed for treatment of relapsing-remitting multiple sclerosis (RRMS). DMF can induce lymphopenia, which is assumed to increase the risk for opportunistic infections like progressive multifocal leukoencephalopathy. Our goal for this work was to estimate the frequency of grade 3 lymphopenia in DMF-treated patients with RRMS and to characterize patient-sided factors influencing the time course of lymphocyte repopulation after DMF withdrawal. Material and methods A single-center retrospective data analysis was performed at University Hospital Bern, Switzerland. Patients with DMF treatment were analyzed for lymphocyte counts. Demographic factors were statistically analyzed in grade 3 lymphopenic patients. Results We estimated a grade 3 lymphopenia frequency of 11/246 (4.5%), corroborating previous studies. In all patients, lymphocytes recovered to values ⩾800/µl within 0.5 years. Multivariate linear regression analysis unmasked older age as being associated with a longer duration of repopulation. Conclusion Considering the aging population, our findings warrant further investigations of DMF-induced lymphopenia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Briner, Myriam Sandra; Bagnoud, Maud Marie; Miclea, Andrei; Friedli, Christoph Daniel; Diem, Lara; Chan, Andrew Hao-Kuang; Hoepner, Robert and Salmen, Anke

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1756-2856

Publisher:

Sage

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

19 Jul 2019 10:19

Last Modified:

21 Jul 2019 02:40

Publisher DOI:

10.1177/1756286419843450

PubMed ID:

31105768

Uncontrolled Keywords:

adverse event age fumarate lymphocytes multiple sclerosis white blood cells

BORIS DOI:

10.7892/boris.131336

URI:

https://boris.unibe.ch/id/eprint/131336

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