Comparison of two accelerated 4D-flow sequences for aortic flow quantification.

Ebel, Sebastian; Dufke, Josefin; Köhler, Benjamin; Preim, Bernhard; Rosemeier, Susan; Jung, Bernd; Dähnert, Ingo; Lurz, Philipp; Borger, Michael; Grothoff, Matthias; Gutberlet, Matthias (2019). Comparison of two accelerated 4D-flow sequences for aortic flow quantification. Scientific Reports, 9(1), p. 8643. Nature Publishing Group 10.1038/s41598-019-45196-x

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To compare two broadly used 4D-flow- with a 2D-flow-sequence in healthy volunteers, regarding absolute flow parameters, image quality (IQ), and eddy current correction (ECC). Forty volunteers (42 ± 11.8 years, 22 females) were examined with a 3T scanner. Thoracic aortic flow was assessed using a 3D-T2w-SPACE-STIR-sequence for morphology and two accelerated 4D-flow sequences for comparison, one with k-t undersampling and one with standard GRAPPA parallel-imaging. 2D-flow was used as reference standard. The custom-made software tool Bloodline enabled flow measurements for all analyses at the same location. Quantitative flow analyses were performed with and without ECC. One reader assessed pathline IQ (IQ-PATH) and occurrence of motion artefacts (IQ-ART) on a 3-point grading scale, the higher the better. k-t GRAPPA allowed a significant mean scan time reduction of 46% (17:56 ± 5:26 min vs. 10:40 ± 3:15 min) and provided significantly fewer motion artefacts than standard GRAPPA (IQ-ART 1.57 ± 0.55 vs. 0.84 ± 0.48; p < 0.001). Neither 4D-flow sequence significantly differed in flow volume nor peak velocity results with or without ECC. Nevertheless, the correlation between both 4D-flow sequences and 2D-flow was better with ECC; the k-t GRAPPA sequence performed best (R = 0.96 vs. 0.90). k-t GRAPPA 4D-flow was not inferior to a standard GRAPPA-sequence, showed fewer artefacts, comparable IQ and was almost two-fold faster.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Jung, Bernd


600 Technology > 610 Medicine & health




Nature Publishing Group




Maria de Fatima Henriques Bernardo

Date Deposited:

22 Jul 2019 12:57

Last Modified:

24 Oct 2019 08:34

Publisher DOI:


PubMed ID:





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