Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study.

Brahimaj, Adela; Rivadeneira, Fernando; Muka, Taulant; Sijbrands, Eric J G; Franco, Oscar H; Dehghan, Abbas; Kavousi, Maryam (2019). Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study. Diabetologia, 62(9), pp. 1581-1590. Springer 10.1007/s00125-019-4921-2

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AIMS/HYPOTHESIS Both visceral and truncal fat have been associated with metabolic disturbances. We aimed to investigate the associations of several novel metabolic indices, combining anthropometric and lipid measures, and dual-energy x-ray absorptiometry (DXA) measurements of body fat, with incident type 2 diabetes among women and men from the large population-based Rotterdam Study. METHODS Cox proportional hazards models were used to investigate associations of visceral adiposity index (VAI), lipid accumulation product (LAP), the product of triacylglycerol and glucose (TyG), their formula components and DXA measures with incident type 2 diabetes. Associations were adjusted for traditional diabetes risk factors. RESULTS Among 5576 women and 3988 men free of diabetes, 511 women and 388 men developed type 2 diabetes during a median follow-up of 6.5 years. In adjusted models, the three metabolic indices VAI (per 1 SD naturally log-transformed HR; 95% CI) (1.49; 1.36, 1.65 in women; 1.37; 1.22, 1.53 in men), LAP (1.35; 1.16, 1.56 in women; 1.19; 1.01, 1.42 in men) and TyG (1.73; 1.52, 1.98 in women; 1.43; 1.26, 1.62 in men), gynoid fat mass (0.63; 0.45, 0.89) and android to gynoid fat ratio (1.51; 1.16, 1.97) in women were associated with incident type 2 diabetes. BMI (1.45; 1.28, 1.65) was the strongest predictor of type 2 diabetes in men. CONCLUSIONS/INTERPRETATION Among women, novel combined metabolic indices were stronger risk markers for type 2 diabetes than the traditional anthropometric and laboratory measures and were comparable with DXA measures. Neither combined metabolic indices nor DXA measures were superior to traditional anthropometric and lipid measures in association with type 2 diabetes among men.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Muka, Taulant and Franco Duran, Oscar Horacio

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0012-186X

Publisher:

Springer

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

25 Jun 2019 09:44

Last Modified:

24 Oct 2019 11:23

Publisher DOI:

10.1007/s00125-019-4921-2

PubMed ID:

31183505

Uncontrolled Keywords:

Android fat BMI Combined indices DXA Epidemiology Gynoid fat LAP TyG Type 2 diabetes VAI

BORIS DOI:

10.7892/boris.131444

URI:

https://boris.unibe.ch/id/eprint/131444

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