Increased admission central venous-arterial CO difference predicts ICU-mortality in adult cardiac surgery patients.

Zante, Björn; Reichenspurner, Hermann; Kubik, Mathias; Schefold, Jörg Christian; Kluge, Stefan (2019). Increased admission central venous-arterial CO difference predicts ICU-mortality in adult cardiac surgery patients. Heart & lung, 48(5), pp. 421-427. Elsevier 10.1016/j.hrtlng.2019.05.015

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BACKGROUND Invasive procedures such as cardiac surgery are associated with perioperative dysfunction of macrocirculation and/or microcirculation and organ failures. Maintenance or resuscitation of an adequate macrocirculation and/or microcirculation is thus crucial in patients after cardiac surgery. We investigated the prognostic power of early central venous-arterial carbon dioxide pressure difference (delta-pCO2) after cardiac surgery. METHODS Retrospective analysis of data from 1,019 cardiac surgery patients treated in the ICU of a tertiary medical care academic center. Clinical outcomes and laboratory measures including metabolic indices and calculated delta-pCO were assessed. Receiver operating characteristic (ROC) curves were generated and sensitivity / specificity analysis was performed. Univariate and multivariate regression models were analyzed. RESULTS The area under the ROC curve for delta-pCO to predict ICU mortality was 0.72 (sensitivity 65% / specificity 76%) with an optimal delta-pCO cut-off value of 8.6 mmHg. In multivariate regression, delta-pCO was associated with increased ICU mortality (HR 3.72, 95%-CI 1.3-10.66, p = 0.02). After adjustment for typical confounders, delta-pCO remained as independent predictor of ICU mortality after cardiac surgery. CONCLUSIONS In a retrospective data analysis in a large sample of adult post cardiac surgery patients treated in the ICU, we observed that admission central venous-arterial delta-pCO independently predicts ICU mortality. Delta-pCO might thus contribute risk stratification in ICU patients after cardiac surgery.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Zante, Björn and Schefold, Jörg Christian


600 Technology > 610 Medicine & health








Mirella Aeberhard

Date Deposited:

26 Jul 2019 14:11

Last Modified:

25 Oct 2019 11:44

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Carbon dioxide content difference Cardiac output Hemodynamic Sepsis Tissue oxygenation Veno-arterial CO(2) difference




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