Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression.

Bourantas, Christos V; Räber, Lorenz; Sakellarios, Antonis; Ueki, Yasushi; Zanchin, Thomas; Koskinas, Konstantinos C; Yamaji, Kyohei; Taniwaki, Masanori; Heg, Dik; Radu, Maria D; Papafaklis, Michail I; Kalatzis, Fanis; Naka, Katerina K; Fotiadis, Dimitrios I; Mathur, Anthony; Serruys, Patrick W; Michalis, Lampros K; Garcia-Garcia, Hector M; Karagiannis, Alexios and Windecker, Stephan (2020). Utility of Multimodality Intravascular Imaging and the Local Hemodynamic Forces to Predict Atherosclerotic Disease Progression. JACC. Cardiovascular imaging, 13(4), pp. 1021-1032. Elsevier 10.1016/j.jcmg.2019.02.026

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This study sought to examine the utility of multimodality intravascular imaging and of the endothelial shear stress (ESS) distribution to predict atherosclerotic evolution.


There is robust evidence that intravascular ultrasound (IVUS)-derived plaque characteristics and ESS distribution can predict, with however limited accuracy, atherosclerotic evolution; nevertheless, it is yet unclear whether multimodality imaging and ESS mapping enable more accurate prediction of coronary plaque progression.


A total of 44 patients admitted with a myocardial infarction that had successful revascularization and 3-vessel IVUS and optical coherence tomography (OCT) imaging at baseline and 13-month follow-up were included in the study. The IVUS data acquired at baseline in the nonculprit vessels were fused with x-ray angiography to reconstruct coronary anatomy and in the obtained models blood flow simulation was performed and the ESS was estimated. The baseline plaque characteristics and ESS distribution were used to identify predictors of disease progression: defined as a lumen reduction and an increase in plaque burden at follow-up.


Seventy-three vessels were included in the final analysis. Baseline ESS and the IVUS-derived but not the OCT-derived plaque characteristics were independently associated with a decrease in lumen area and an increase in plaque burden. Low ESS (odds ratio: 0.45; 95% confidence interval: 0.28 to 0.71; p < 0.001) and plaque burden (odds ratio: 0.73; 95% confidence interval: 0.54 to 0.97; p = 0.030) were the only independent predictors of disease progression at follow-up. The accuracy of the IVUS-derived plaque characteristics in predicting disease progression did not improve when ESS (AUC: 0.824 vs. 0.847; p = 0.127) or when OCT variables and ESS (AUC: 0.842; p = 0.611) were added into the model.


ESS and OCT-derived variables did not improve the efficacy of IVUS in predicting disease progression. Further research is required to investigate whether multimodality imaging combined with ESS mapping will allow more reliable vulnerable plaque detection. (Comparison of Biomatrix Versus Gazelle in ST-Elevation Myocardial Infarction [STEMI] [COMFORTABLE]; NCT00962416).

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Räber, Lorenz, Ueki, Yasushi, Zanchin, Thomas, Koskinas, Konstantinos, Yamaji, Kyohei, Taniwaki, Masanori, Heg, Dierik Hans, Karagiannis Voules, Alexios, Windecker, Stephan


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Andrea Flükiger-Flückiger

Date Deposited:

25 Jun 2019 11:44

Last Modified:

05 Dec 2022 15:29

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

atherosclerosis endothelial shear stress intravascular ultrasound optical coherence tomography





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