Membrane trafficking and organelle biogenesis in Giardia lamblia: use it or lose it.

Faso, Carmen; Hehl, Adrian B (2011). Membrane trafficking and organelle biogenesis in Giardia lamblia: use it or lose it. International journal for parasitology, 41(5), pp. 471-480. Elsevier 10.1016/j.ijpara.2010.12.014

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The secretory transport capacity of Giardia trophozoites is perfectly adapted to the changing environment in the small intestine of the host and is able to deploy essential protective surface coats as well as molecules which act on epithelia. These lumen-dwelling parasites take up nutrients by bulk endocytosis through peripheral vesicles or by receptor-mediated transport. The environmentally-resistant cyst form is quiescent but poised for activation following stomach passage. Its versatility and fidelity notwithstanding, the giardial trafficking systems appear to be the product of a general secondary reduction process geared towards minimization of all components and machineries identified to date. Since membrane transport is directly linked to organelle biogenesis and maintenance, less complexity also means loss of organelle structures and functions. A case in point is the Golgi apparatus which is missing as a steady-state organelle system. Only a few basic Golgi functions have been experimentally demonstrated in trophozoites undergoing encystation. Similarly, mitochondrial remnants have reached a terminally minimized state and appear to be functionally restricted to essential iron-sulfur protein maturation processes. Giardia's minimized organization combined with its genetic tractability provides unique opportunities to study basic principles of secretory transport in an uncluttered cellular environment. Not surprisingly, Giardia is gaining increasing attention as a model for the investigation of gene regulation, organelle biogenesis, and export of simple but highly protective cell wall biopolymers, a hallmark of all perorally transmitted protozoan and metazoan parasites.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology
08 Faculty of Science > Department of Biology > Institute of Cell Biology > Parasitologie

UniBE Contributor:

Faso, Carmen

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0020-7519

Publisher:

Elsevier

Language:

English

Submitter:

Carmen Faso

Date Deposited:

27 Sep 2019 11:03

Last Modified:

23 Oct 2019 00:39

Publisher DOI:

10.1016/j.ijpara.2010.12.014

PubMed ID:

21296082

BORIS DOI:

10.7892/boris.131622

URI:

https://boris.unibe.ch/id/eprint/131622

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