Inferior frontal gyrus gray matter volume is associated with aggressive behavior in schizophrenia spectrum disorders.

Schoretsanitis, Georgios; Stegmayer, Katharina Deborah Lena; Razavi, Nadja; Federspiel, Andrea; Müller, Thomas; Horn, Helge Joachim; Wiest, Roland; Strik, Werner; Walther, Sebastian (2019). Inferior frontal gyrus gray matter volume is associated with aggressive behavior in schizophrenia spectrum disorders. Psychiatry research: Neuroimaging, 290, pp. 14-21. Elsevier 10.1016/j.pscychresns.2019.06.003

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We aimed to assess potential gray matter (GM) alterations for aggressive patterns of behavior in a sample of in- and outpatients with schizophrenia spectrum disorders. Eighty-four patients previously participating in brain volumetric studies were included. Aggression was assessed using the Modified Overt Aggression Scales (MOAS) based upon review of clinical records of the hospital register. Multiple regression analyses for total MOAS and each MOAS subscale separately were conducted correcting for age, sex, history of addiction, chlorpromazine equivalents, illness duration, and total intracranial volume. Significant effects were reported in two cases; the total MOAS scores and MOAS verbal aggression scores were associated with GM volume in left inferior frontal gyrus. From the demographic/clinical characteristics, only the number of episodes correlated with the subscales and the total MOAS scores. Our results highlight the role of GM volume in left inferior frontal gyri in patients with history of aggression. This evidence ties in well with previous data reporting involvement of these regions in response control and semantic networks.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Schoretsanitis, Georgios, Stegmayer, Katharina Deborah Lena, Razavi, Nadja, Federspiel, Andrea, Müller, Thomas (A), Horn, Helge Joachim, Wiest, Roland Gerhard Rudi, Strik, Werner, Walther, Sebastian


600 Technology > 610 Medicine & health








Martin Zbinden

Date Deposited:

14 Aug 2019 12:00

Last Modified:

29 Mar 2023 23:36

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Aggression Gray matter volume Schizophrenia State markers Violence




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