Autoantibodies Against Albumin in Patients With Systemic Lupus Erythematosus.

Nehring, Josephine; Schirmbeck, Lucia A; Friebus-Kardash, Justa; Dubler, Denise; Huynh-Do, Uyen; Chizzolini, Carlo; Ribi, Camillo; Trendelenburg, Marten (2018). Autoantibodies Against Albumin in Patients With Systemic Lupus Erythematosus. Frontiers in immunology, 9(2090), p. 2090. Frontiers Research Foundation 10.3389/fimmu.2018.02090

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Autoantibodies and aberrant immune complexes are pathological hallmarks of systemic lupus erythematosus (SLE). This study aimed to determine the occurrence of IgG autoantibodies against human serum albumin (anti-HSA IgG) and their potential association with antibodies against bovine serum albumin (anti-BSA IgG) in patients with SLE. Sera of 180 SLE patients included to the Swiss SLE Cohort Study and 188 age- and sex-matched healthy controls were evaluated. Levels of anti-HSA IgG and anti-BSA IgG were quantified by ELISA. Selected samples were further characterized using serum fractions obtained by fast liquid chromatography (FPLC). SLE patients had increased levels of anti-HSA IgG ( = 0.002) but similar levels of anti-BSA IgG compared to matched healthy controls. Anti-HSA IgG levels correlated with the SLE Disease Activity Index (SLEDAI), which was more pronounced in patients with an physician's global assessment (PGA) of ≥ 1 ( = 0.309, = 0.0066). Anti-HSA IgG was partially complexed with serum albumin but also occurred as monomeric autoantibodies in highly positive SLE patients. A positive correlation between anti-HSA IgG and anti-BSA IgG was found that was stronger in SLE patients than in healthy controls ( = 0.3172, < 0.001 vs. = 0.2122, < 0.0035). Binding of anti-BSA IgG was inhibited partially in the presence of HSA in samples with double positivity for anti-HSA and anti-BSA (median inhibition 47.9%, range 0.9-100%) and vice versa. In SLE patients there is an increased prevalence of anti-HSA IgG antibodies that are associated with SLE disease activity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Huynh-Do, Uyen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Uyen Huynh-Do

Date Deposited:

17 Sep 2019 13:26

Last Modified:

24 Oct 2019 09:05

Publisher DOI:

10.3389/fimmu.2018.02090

PubMed ID:

30333817

Uncontrolled Keywords:

antibodies human serum albumin multicenter study patients systemic lupus erythematosus

BORIS DOI:

10.7892/boris.131732

URI:

https://boris.unibe.ch/id/eprint/131732

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